Definition example

Definitive examples of intrinsic non-RRKM dynamics for molecules excited near their unimolecular tluesholds are rather limited. Calculations have shown that intrinsic non-RRKM dynamics becomes more pronounced at very high energies, where the RRKM lifetime becomes very short and dissociation begins to compete with IVR [119]. There is a need for establishing quantitative theories (i.e. not calculations) for identifying which molecules and energies lead to intrinsic non-RRKM dynamics. For example, at thenual... 

In addition to effects on biochemical reactions, the inhibitors may influence the permeability of the various cellular membranes and through physical and chemical effects may alter the structure of other subcellular structures such as proteins, nucleic acid, and spindle fibers. Unfortunately, few definite examples can be listed. The action of colchicine and podophyllin in interfering with cell division is well known. The effect of various lactones (coumarin, parasorbic acid, and protoanemonin) on mitotic activity was discussed above. Disturbances to cytoplasmic and vacuolar structure, and the morphology of mitochondria imposed by protoanemonin, were also mentioned. Interference with protein configuration and loss of biological activity was attributed to incorporation of azetidine-2-carboxylic acid into mung bean protein in place of proline. 

Let us consider as a definite example a benzene molecule, which may have different substituent groups in the 1, 2, , 6 posi-... 

The only definite examples are the acyl transfer reactions of acylcorrinoids, discovered by Bernhauer and Irion 14), and later studied in more detail by Yamada et al. 180). These reactions can be written... 

Compounds containing the iV-thiosulfinylamino group (R—N=S=S) have been reported recently.85 "88 The aryl compounds are rather unstable purple oils which show promise as sulfur transfer agents, although few definitive examples have yet been reported.87... 

This is certainly not the only possibility, and MQSM can be defined using many choices of il(ir,r2) provided it remains positive definite. Examples include the Coulomb MQSM and kinetic QSM. In case of the Coulomb operator, one does not perform the point-by-point similarity calculation as in Equation 16.4 but introduces weighting of the surrounding points using as an operator ... 

Level of Hierarchy Approximate Number of Terms Definition Example... 

Definitive example of successful gene therapy in two patients suffering from ADA-SCID. More patients need to be enrolled in similar trials to confirm the safety, efficacy and optimization of the therapy, and also with regard to the requirement of nonmyeloablative conditioning. 

The formation of anionic -adducts resulting from the primary attachment of neutral nucleophiles followed by proton elimination has been described only occasionally. A definite example is the reaction of methyl-amine with 2-nitrophenazine 10-oxide in DMF, leading to adduct 118.161 This structure is well supported by spectral evidence. It is characterized by two... 

Without definite examples to focus our thinking, it is easy to get entangled in a quasi-philosophical discussion of just what a mathematical model might be. To avoid this, I present a dogmatic statement on modeling and proceed to consider an elementary example, returning later to the philosophical caveats and more general considerations. 

The distinction we have made between unsaturated and reactive is best illustrated by a definite example. Ethene is unsaturated (and reactive )... 

Pentacoordinate organocobalt(III) species have been suspected to exist either as reactive intermediates in ligand-exchange reactions [137-141] or, less commonly, as relatively stable species [140-142], Clear-cut demonstrations of stable 5-coordinate Co(III) complexes are relatively rare [136,143], One report contains two definitive examples of 5-coordinate complexes of the type Co(saloph)R (R = CH3 and /-C3H7) [136], Several interesting features emerge from these structures. First, the Co atom is displaced toward R. Second, the Co—C bond is shorter than in hexacoordinate compounds, but steric strain remains for z -C3H7, even in the pentacoordinate species. 

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