Progesterone injection

Pregnancy Category D (progesterone injection) Catego/y X(norethindrone acetate). Use is not recommended. See Warning Box. 

Carol s severe PMS was the next thing to go. The doctor who had been giving her progesterone injections was sent to jail (for heresy rather than malpractice, Carol remarked), so she had no source for the progesterone shots. 

First of all, progesterone injected directly into oocytes also can be extracted and coprecipitated with protein. Maturation is not induced under these conditions (see earlier discussion). 

For example, the label of a prescription drug to be administered in the vein reads, testosterone propionate injection with benzyl alcohol as a preservative 10%, in sesame oil . Cocoa butter is a constituent of pro-menthazine hydrochloride used either orally or by suppositories for perennial and seasonal allergic rhinitis. It is manufactured by Wyeth Laboratories, Inc., Philadelphia, PA. Progesterone injection, USP, in sesame oil is used for intramuscular use only (manufactured by Steris Laboratories, Phoenix, AZ). 

Progesterone. Progesterone (1) is not orally active. Although seldom used clinically, it can be adrninistered as an intramuscular injection, pessaries, or suppositories in the treatment of menstmal disorders and habitual abortion (121). Progesterone can be recrystaUized from dilute alcohol and exists in two crystalline forms (122). It is soluble in chloroform and ethanol sparingly soluble in acetone, dioxane, ether, and fixed oils and practically insoluble in water (121). Two syntheses of progesterone (1) are described in Figure 3. 

Watanuki, H., Yamaguchi, T., and Sakai, M. (2002). Suppression in function of phagocytic cells in common carp Cyprinus carpio L. injected with estradiol, progesterone or 11-ketotestosterone. Comparative Biochemistry and Physiology C—Toxicology and Pharmacology 132, 407 13. 

The release of steroids such as progesterone from films of PCL and its copolymers with lactic acid has been shown to be rapid (Fig. 10) and to exhibit the expected (time)l/2 kinetics when corrected for the contribution of an aqueous boundary layer (68). The kinetics were consistent with phase separation of the steroid in the polymer and a Fickian diffusion process. The release rates, reflecting the permeability coefficient, depended on the method of film preparation and were greater with compression molded films than solution cast films. In vivo release rates from films implanted in rabbits was very rapid, being essentially identical to the rate of excretion of a bolus injection of progesterone, i. e., the rate of excretion rather than the rate of release from the polymer was rate determining. 

Initial dose 5 mg/day for 2 weeks increase in increments of 2.5W mg/day every 2 weeks up to 15 mg/day. Therapy may be held at this level for 6 to 9 months or until breakthrough bleeding demands temporary termination. PROGESTERONE For IM use. The drug is irritating at the injection site. 

It is a synthetic progestogen structurally related to progesterone given orally or by IM injection. 

Higashi and coworkers [28] used 2-hydrazino-l-methylpyridine (HMP) derivatization to introduce a positively charged moiety in testosterone and dihydrotestosterone (DHT) to achieve a sensitivity improvement of 70- to 1600-fold compared to underivatized molecules in ESI. However, they found the derivative was unsuitable for di-keto steroids such as androstenedione and progesterone, so this form of derivatization is unlikely to be widely accepted. Separable syn- and anti- (E and Z) stereoisomers are formed using this derivative. Preparation is as follows a solution of 10 pg HMP in 50 pi ethanol containing 25 pg TFA was added to the steroid dissolved in 30 pi ethanol. After heating for 1 h at 60 C, the solvents can be removed and sample injected. 

Norgestomet, a synthetic derivative of progesterone, has been widely used for synchronization of estrous in cattle. It is administered with an intramuscular injection in combination with a subcutaneous ear implant that contains 3 mg norgestomet and is removed after 9-10 days. 

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