Probenecid interaction

Salicylates [P] Decreased uricosuric effect of probenecid (interaction unlikely with less than 1.5 g of salicylate daily). 

Runkel R, Mroszczak E, Chaplin M, et al. Naproxen-probenecid interaction. Clin Pharmacol Ther 1978 24(6) 706-713. 

Meffin PJ, Zilm DM, Veenendaal JR, et al. A renal mechanism for the clofibric acid-probenecid interaction. J Pharmacol Exp Ther 1983 227(3) 739-742. 

Brooks PM, Bell MA, Sturrock RD, Famaey JP, Dick WC. The clinical significance of indomethacin-probenecid interaction. Br J Chn Pharmacol 1974 1 287. 

Chennavasin P, Seiwell R, Brater DC, Liang WMM. Pharmacodynamic analysis of the furo-semide-probenecid interaction in man. Kidney Int 919 ) 16,187-95. 

If the unbound drug concentrations in plasma are higher than their K values on the transporters, then transporter function may be significantly affected [106], Following a pharmacokinetic analysis of the effect of probenecid on the hepatobiliary excretion of methotrexate, it has been shown the extent of an in vivo drug-drug interaction can be quantitatively predicted from the kinetic parameters for transport across the sinusoidal and bile canalicular membranes determined in vitro [107]. 

Ueda, K., Kato, Y., Komatsu, K., Sugiyama, Y., Inhibition of biliary excretion of methotrexate by probenecid in rats quantitative prediction of interaction from in vitro data, J. Pharmacol. Exp. Ther. 2001,... 

C. A., Sugiyama, Y., The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites, Drug Metab. Pharmacokinet. 2002, 17, 23-33. 

Agents that may interact with cephalosporins include ethanol, aminoglycosides, anticoagulants, polypeptide antibiotics, probenecid, antacids, H2antagonists, iron... 

Drugs that may interact with imipenem-cilastatin include ganciclovir, probenecid, and cyclosporine. 

Drugs that may interact with nalidixic acid include theophylline, caffeine, oral anticoagulants, bacteriostatic agents, probenecid, antacids (containing magnesium, aluminum, and calcium), sucralfate, iron salts, multivitamins containing zinc, didanosine, antiarrhythmic agents, and melphalan. 

Drugs that may interact with acyclovir include hydantoins, probenecid, theophylline, valproic acid, and zidovudine. 

The conversion of 6-deoxy penciclovir to penciclovir is catalyzed by aldehyde oxidase. Interactions with other drugs metabolized by this enzyme could occur. Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir. Drug/Food interactions When famciclovir was administered with food, penciclovir Cmax decreased approximately 50%. Because the systemic availability of penciclovir (AUC) was not altered, it appears that famciclovir may be taken without regard to meals. 

Drugs that may interact with zalcitabine include antacids, chloramphenicol, cisplatin, dapsone, didanosine, disulfiram, ethionamide, glutethimide, gold, hydralazine, iodoquinol, isoniazid, metronidazole, nitrofurantoin, phenytoin, ribavirin, vincristine, cimetidine, metoclopramide, amphotericin, aminoglycosides, foscarnet, antiretroviral nucleoside analogs, pentamidine, and probenecid. 

Bismuth Subsalicylate (Pepto-Bismol) [Antidiarrheal/ Adsorbent] [OTC] Uses Indigestion, N, D combo for Rx of H. pylori Infxn Action Antisecretory anti-inflammatory E>o e Adults. 2 tabs or 30 mL PO PRN (max 8 doses/24 h) Feds. 3—6 y 1/3 tab or 5 mL PO PRN (max 8 doses/24 h) 5-9 y 2/3 tab or 10 mL PO PRN (max 8 doses/24 h) 9-72 y 1 tab or 15 mL PO PRN (max 8 doses/24 h) Caution [C, D (3rd tri), -] Avoid w/ renal failure Hx severe GI bleed Contra Influenza or chickenpox (T risk of Reye synd), ASA allergy (see Aspirin) Disp Chew tabs, caplets, Liq, susp SE May turn tongue stools black Interactions T Effects OF ASA, MTX, valproic acid effects OF tetracyclines i effects W/ corticosteroids, probenecid EMS Monitor for hypovolemia and electrolyte disturbances d/t D may darken tongue stool OD Similar to ASA OD V, tinnitus, metabolic acidosis activated charcoal may be effective... 

Uses Infxns of the resp tract, skin, bone, urinary tract Action 3rd-gen cephalosporin -1- cell wall synth Dose Adults. 400 mg PO daily-bid Peds. 8-20 mg/kg/d PO daily—bid -1- in renal impair Caution [B, +] Contra Cephalosporin allergy Disp Susp SE N/V/D, flatulence, abd pain Interactions t Nqjhrotox W/ aminoglycosides, loop diuretics t effects W/ nifedipine, probenecid EMS t Risk of nephrotox w/ loop diuretics monitor for signs of electrolyte disturbances and hypovolemia d/t D monitor pt for super Infxn OD May cause N/V/D, Szs, muscles spasms symptomatic and supportive... 

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