Primula obconica

Derivatives. Scopoletin [92-61-5] (6-methoxyumbelliferone) (38) occurs, for example, in Sokmaceae as a growth factor in plants. Primin [15121-94-5] (2-methoxy-6-pentyl-l,4-benzoquinone) is a skin irritant isolated from Primula obconica. Versicolin [438944-0]... 

The first experimental sensitizations on man were made by Nestler (1904), Cash (1911) and Low (1924). Bloch and Steiner-Wourlisch(1926 and 1930) were the first to sensitize, using the same method (concentrated extracts of Primula obconica) man and the guinea pig. The latter authors have shown that the histological lesions in man are similar to those of the spontaneous eczema caused by Primula and that the histological lesions of the patch test in guinea pigs also show a great similarity to those observed in man. 

Machaerium scleroxylon) in a hobbyist handling the wood. Plants reported to cause erythema multiformelike eruption include poison ivy (Toxicodendron) (Schwartz and Downham 1981 Mallory et al. 1982), primula Primula obconica) (Hjorth 1966) and mug-wort (Artemesia vulgaris) (Kurz and Rapaport 1979). Mallory et al. (1982) reported urticarial eruptions with black deposits on the skin of four patients with Toxidocendron radicans dermatitis. Urticaria, erythema multiforme-like eruptions, in a patient from Rhus dermatitis was reported by Schwartz and Down-ham (1981). They recommended that patients with such reactions should be screened for systemic involvement as previous reports have shown that nephritis can be an associated feature (Meneghini and AngeUni 1981 Fisher 1986). 

Primula dermatitis can be occupational [117], but usually one sees an older housewife with a dermatitis of the fingertips and streaks and patchy eczema on the hands, face [118] (especially the eyelids) [119] and arms [9, 120]. Primula obconica (Fig. 9) is such a common contact allergen in Europe that about i.o-i.8% of persons routinely patch tested react to the causative allergen, primin (0.01% in petrolatum) as part of the European screening series [118]. The eruption may not be suspected until the positive patch test appears [118], and the nondescript pattern may suggest an endogenous cause [118]. Rarely, one sees a reaction to the plant when the patch test to primin is negative [121]. 

Contact dermatitis from Primula obconica Hance. Contact Dermatitis 16 195-197 150. 

Geraniol 2% (fragrant geraniums [Pelargonium spp.]) Primin Primula obconica)y 0.01%... 

Primula obconica allergy appears to be decreasing in parts of western Europe (Paulsen 1998) attempts are being made to breed cultivars that have lower concentrations of primin, the major allergen. It is unclear whether other Primula species are significant allergens. 

Primin is the allergen of Primula obconica. Occupational contact dermatitis occurs mainly in florists and horticulturists. 

Primary allergen of the plant Primula obconica found in glandular hairs on the leaves and the stem. ABCD from contact with Primula Synonyms i-isopropyl-3-methyl-s-pyrazolyldimethyl carbamate Primin 2-methoxy-6-pentylbenzoquinone dimethylcarbamic acid 3-methyl-i-(i-methylethyl)-iH-pyrazol-5-yl ester isopropylmethylpyrazolyl dimethylcarbamate dimethylcarbamic acid i-isopropyl-3-methyl-pyrazol-5-yl ester dimethyl-5-(isopropyl-3-methyl-pyrazolyl)carbamate isopropyl-3-methylpyrazoi-5-yl dimethylcarbamate Isolan Saolan... 

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