Prevention by chitosan

Kimura, Y. Okuda, H. Prevention by chitosan of myelotoxicity, gastrointestinal... 

Y. Kimura, and H. Okuda, Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-fluorouracil without loss of antitumor activity in mice, Jpn. J. Cancer Res., 90 (7), 765-774,1999. 

Note that some treatment operations choose a pollution prevention technique to dispose of the float. This involves feeding the float to animals. When this is done for the situation where the feed animals are used for human consumption, organic compounds such as chitosan, carrageenan, lignosulfonic acid,or their derivatives can be used. Use only compounds that are approved by the Food and Drug Administration (FDA) Office of Veterinary Medicine. 

FU (12.5 mg/kg twice daily) plus chitosan (150, 375 and 750 mg/kg twice daily) inhibited the tumor growth as well as 5-FU alone. Chitosan (150 and 750 mg/kg twice daily) blocked the reduction of blood leukocyte number caused by 5-FU administration, and it prevented the injury of the small intestinal mucosa membrane and delayed the onset of diarrhea induced by 5-FU Fig. (1), Fig. (2) and Fig. (3) . Furthermore, chitosan (750 mg/kg twice daily) prevented the reduction of spleen weight induced by 5-FU in sarcoma 180-bearing mice Fig. (4) , and the reduction of lymphocyte, CD8+ and NK1.1.+ T cell numbers induced by 5-FU Fig. (5) . 

Gastrointestinal toxicity and myelotoxicity are caused by the 5-FU after its phosphorylation in the digestive tract and bone marrow tissue. To clarify whether chitosan enhances the antitumor activity of 5-FU and prevents the side effects induced by 5-FU, we examined the antitumor activity and side effects, such as myelotoxicity, immimocompetent organ toxicity, and gastrointestinal toxicity of combined treatment with chitosan and 5-FU in sarcoma 180-beaiing mice. 

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