Prevention by antioxidants

Sastre, J., Asensi, M., Gasco, E., Pallardo, F.V., Ferrero, J.A., Furukawa, T. and Vina, J. (1992). Exhaustive physical exercise causes oxidation of glutathione status in blood prevention by antioxidant administration. Am. J. Physiol. 263, R992-R995. 

Methyl vinyl ether is rapidly hydrolysed by contact with dilute acids to form acetaldehyde, which is more reactive and has wider flammability limits than the ether [1], Presence of base is essential during storage or distillation of the ether to prevent rapid acid-catalysed homopolymerisation, which is not prevented by antioxidants. Even mildly acidic solids (calcium chloride or some ceramics) will initiate exothermic polymerisation [2],... 

LDL oxidation is prevented by antioxidant molecules (11). On average, one LDL particle contains about 6 molecules of a-tocopherol [11], with lowest and highest a-tocopherol contents of 3 and 10 molecules [11]. The reason for this high variation is not clear, but it is reasonable to assume that it reflects to some extent the different dietary conditions. 

Kovacic P, Thurn LA. Cardiovascular toxicity from the perspective of oxidative stress, electron transfer and prevention by antioxidants. Curr Vase Pharmacol2005 3(2) 107—17. 

Sastre J, Asensi M, Cased E, Ferrero JA, Furukawa T,Vina J (1992) Exhaustive physical exercise causes and oxidation of glutathione status in blood. Prevention by antioxidant administration. Am J Physiol 263 R992-R995... 

De la Asuncion JG, del Olmo ML, Sastre J, Millan A, Pellin A, Pallardo FV,Vina J (1998) AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins. J Clin Invest 102(l) 4—9... 

Young, V.W., Perry, T.L. and Krisman, A.A. (1986) Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine is prevented by antioxidant treatment. Neurosci, Lett. 63 56-60. 

Hirose M, Futakuchi M, Tanaka H, Orita SI, Ito T, Miki T, Shirai T. Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay results of extended and combination treatment experiments. Eur J Cancer Prev 1998 7 61-67. 

Carp, H., and Janof, A., 1978, A possible mechanism of emphysema in smokers In vitro suppression of serum elastase inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants. Am. Rev. Respir. Dis. 118 617-621. 

Stoner, G.D., Wang, L.S., and Casto, B.C. 2008. Laboratory and clinical studies of cancer chemo-prevention by antioxidants in berries. Carcinogenesis. 29(9) 1665-1674. 

It is known that in most food the browning process (Fig. 6.50) has two components enzymatic and non-enzymatic oxidation. The non-enzymatic oxidation can be prevented by antioxidants, while tyrosinase inhibitors are applied to prevent enzymatic oxidation. 

---