Preparative layer chromatography pharmaceutical applications

Taylor and co-workers further demonstrated the value of open-access LC/MS systems for generating a widened scope of pharmaceutical analysis applications, including (1) characterization of synthetic intermediates and target compounds (2) reaction monitoring (3) reaction optimization (4) analysis of preparative HPLC fractions and (5) analysis of thin layer chromatography (TLC) plate spots. The availability of these methods led to the increased use of LC/MS for structural analysis. The short analysis time and reliable structure confirmation resulted in the use of LC/MS as a first choice for structure characterization for synthetic chemistry applications, as well as an expanded, and perhaps, integrated role of sample generator and analyst. 

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