3/3 Acetoxy 20/3 hydroxy 5 pregnene

The reduction of pregnenolone acetate to 3/3-acetoxy-20/3-hydroxy-5-pregnene (1, 622, ref. 11) has been published.1... [Pg.97]

F/uoro-11, 17a-D/hydroxy-21-Acetoxy-4-Pregnene-3,20-Dione (6 -F/uorohydrocort/sone Acetate) A solution of 100 mg of 5a,11i3,17a-trihydroxy-6j3-fluoro-21-acetoxyallopregnane-... [Pg.686]

A solution of 1.0 g of A -3,11-diketo-20-cyano-21-acetoxy-pregnene in 10 cc of benzene is treated with 1.0 g of osmium tetroxide and 0.43 g of pyridine. After standing at room temperature for 18 hours, the resulting solution is treated successively with 50 cc of alcohol, and with 50 cc of water containing 2.5 g of sodium sulfite. The mixture is stirred for 30 hours, filtered, and the filtrate acidified with 0.5 cc of acetic acid and concentrated to small volume in vacuo. The aqueous suspension is then extracted four times with chloroform, the chloroform extracts are combined, washed with water and concentrated to dryness in vacuo. Recrystallization of the residue from acetone gives 3,11,20-triketo-17(a)-21-dihydroxy-pregnane MP 227° to 229°C. This compound is then treated with acetic anhydride and pyridine for 15 minutes at room temperature to produce 3,11,20-triketo-17(a)-hydroxy-21-acetoxy-pregnane or cortisone acetate. [Pg.390]

Acetoxy-18-hydroxy-18,20/3-oxido-5-pregnene, oxidation to 18,20-lac-tone, 46, 57... [Pg.119]

Iodine in functionalization of C 19 meth> 1 group of 3d acetoxy 20/3 hydroxy 5 pregnene 46, 58 Iron powder in preparation of ketones from carboxylic acids, 47, 75 Isobutene, 45, 49... [Pg.131]

Analog erhalt man ausgehend von 3/3-Hydroxy-16a-acetoxy-20-oxo-pregnen-(5) 7 6u-Acetoxy-3,20-dioxo-pregnen-(4)5. [Pg.514]

C24H3iFO. 50763-89-8) see Diflorasone diacetate 21-acetoxy-3 0-dioxo-6a-fluoro-l 1 P-hydroxy- 16a-methyl-4-pregnene... [Pg.2281]

B. 3 -Acetoxy-18-iodo- and 18-hydroxy-18,20 -oxido-5-pregnene. In a 5-1. three-necked flask fitted with a mechanical stirrer, a thermometer, and a reflux condenser are placed 31. of cyclohexane (Note 6), 180 g. ca. 0.37 mole) of commercial lead tetraacetate containing approximately 10% acetic acid (Note 7), 24 g. (0.095 mole) of iodine and 30 g. (0.083 mole) of 3j3-acetoxy-20j8-hydroxy-5-pregnene. The reaction mixture is stirred and heated to the boiling point by irradiation with a 1000-watt lamp (Note 8) from underneath. When the iodine color has disappeared (usually after about 60-90 minutes) (Note 9), the reaction mixture is cooled to room temperature, filtered with suction, and the... [Pg.30]

A solution of 250.0 mg of S4-3,20-dioxo-6a,7a-oxido-17a-acetoxy-19-norpregnene in 15 ml of 1 N hydrochloric acid in dioxan is kept for 1 h at 25°C, then poured into water and neutralized with sodium bicarbonate solution. The precipitated crude product is dissolved in a 5 1 mixture of ether and methylene chloride, washed with water until the washings run neutral, and the solution is dried and evaporated under vacuum to give the S4-3,20-dioxo-6-chloro-7a-hydroxy-17a-acetoxy-19-nor-pregnene. [Pg.207]

The crude 84-3,20-dioxo-6-chloro-7a-hydroxy-17a-acetoxy-19-nor-pregnene is dissolved in 3 ml of pyridine, mixed at 5°-0°C with 0.3 ml of methanesulphonyl chloride while being stirred, and the mixture is kept for 2 days at 10°C. The reaction product is then poured into dilute sodium bicarbonate solution, dissolved in ether, and the ethereal solution is washed until the washings run neutral, dried and evaporated under vacuum and the 84-3,20-dioxo-6-chloro-7a-mesyloxy-17a-acetoxy-19-norpregnene is obtained. [Pg.207]

Chemical Name 21-Acetoxy-17-butyryloxy-lip-hydroxy-6a-methyl-4-pregnene-3,20-dione... [Pg.237]

Lead tetraacetate, assay for, 46, 63 in functionalization of C-19 methyl group of 3/3-acetoxy-2O0-hydroxy-5-pregnene, 46, 58... [Pg.67]

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