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18-Hydroxy-18,20£-oxido-5-pregnene

B. 3 -Acetoxy-18-iodo- and 18-hydroxy-18,20 -oxido-5-pregnene. In a 5-1. three-necked flask fitted with a mechanical stirrer, a thermometer, and a reflux condenser are placed 31. of cyclohexane (Note 6), 180 g. ca. 0.37 mole) of commercial lead tetraacetate containing approximately 10% acetic acid (Note 7), 24 g. (0.095 mole) of iodine and 30 g. (0.083 mole) of 3j3-acetoxy-20j8-hydroxy-5-pregnene. The reaction mixture is stirred and heated to the boiling point by irradiation with a 1000-watt lamp (Note 8) from underneath. When the iodine color has disappeared (usually after about 60-90 minutes) (Note 9), the reaction mixture is cooled to room temperature, filtered with suction, and the... [Pg.30]

Stereospecific reduction. AIM soln. of diisobutylaluminum hydride in toluene added dropwise with stirring at —20 to —23° under dry Ng during 15 min. to a suspension of 3,3 20,20-bis(ethylenedioxy)-llj -hydroxy-J5-pregnen-18-oic acid (18- 1 ly ) lactone in anhydrous toluene, and the product isolated after a total of 2 hrs. 3,3 20,20-bis(ethylenedioxy)-ll, 18-oxido-18-hydroxy-(18S)-J -pregnene. Y 85%. F. e. and isomerization of the product s. J. Schmidlin and A.Wettstein, Helv. 46, 2799 (1963). [Pg.281]

Acetoxy-18-hydroxy-18,20/3-oxido-5-pregnene, oxidation to 18,20-lac-tone, 46, 57... [Pg.119]

Chromium trioxide, in oxidation of 18-iodo- and 18-hydroxy-18,2O0-oxido-5-pregnene to 18,20-lactone, 46, 59... [Pg.124]

Hydroxyglutakonitrile, 46, 48 H> droxylamine O sulfonic acid, addi tion to cyclohexanone, 46, 83 18 Hydroxy 18,20/1 oxido-5 pregnene, 46,56... [Pg.131]

A solution of 250.0 mg of S4-3,20-dioxo-6a,7a-oxido-17a-acetoxy-19-norpregnene in 15 ml of 1 N hydrochloric acid in dioxan is kept for 1 h at 25°C, then poured into water and neutralized with sodium bicarbonate solution. The precipitated crude product is dissolved in a 5 1 mixture of ether and methylene chloride, washed with water until the washings run neutral, and the solution is dried and evaporated under vacuum to give the S4-3,20-dioxo-6-chloro-7a-hydroxy-17a-acetoxy-19-nor-pregnene. [Pg.207]

C3,h o,n 21 -hydroxy -17(3,20a -oxido -16-oximino-4-pregnene-3,11-dione 21-OAc 21-OH "" Flavobacterium dehydrogenans — N-686... [Pg.132]

See other pages where 18-Hydroxy-18,20£-oxido-5-pregnene is mentioned: [Pg.125]    [Pg.722]    [Pg.669]    [Pg.119]    [Pg.76]    [Pg.73]    [Pg.125]    [Pg.669]    [Pg.669]    [Pg.140]    [Pg.140]    [Pg.140]    [Pg.318]    [Pg.326]    [Pg.386]    [Pg.405]    [Pg.428]   
See also in sourсe #XX -- [ Pg.45 ]



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