Prednisone 21-acetate

The system just described has been modified to identify corticosteroidal salts, including cortisone acetate. The solvent is a saturated solution of formamide in a 1 1 mixture of benzene and chloroform. Development is descending, until the solvent front has advanced about 22 cm [2,125], and the spot location is the same as described for the preceding method. The reported Rf values were cortisone acetate = 0.80, hydrocortisone acetate = 0.59, prednisone acetate = 0.74, and prednisolone acetate = 0.49. 

The increase in potency observed in the progestin series by incorporation of additional unsamration in the A ring (see delmadinone, (5-4) obtains in the corticoid series as well the majority of commercial steroid anti-inflamatories in fact include this feamre. The double bond at the 1 position may be formed by fermentation with an organism such as Corynebacterium simplex [11] or by reaction with selenium dioxide. Hydrocortisone acetate (13-4) yields the widely used corticoid prednisolone acetate (14-1) in the same vein, cortisone acetate (13-5) goes to prednisone acetate (14-2). Mild saponification of either of these products yields the free alcohols prednisolone and prednisone, respectively. 

Steroid Dienones. Steroids have proved useful tools in organic photochemistry as they have in so many other areas. Irradiation of prednisone acetate (Formula 47) in ethanol gives Formulas 48 and 49 rather than analogs of lumisantonin (Formula 29) (36). In dioxane solution prednisone acetate (Formula 47) gives the phenol (Formula 50). Irradi-... 

Formula 46) in the irradiation of the dienone (Formula 56) has also been shown to involve Formula 45 as an intermediate (35). The difference in the nature of the photochemical rearrangements of prednisone acetate (Formula 47) and santonin (Formula 28) appears to be associated with the absence of a 4-methyl group in prednisone acetate (see Secs. IIA,4 and IIA,7). 

Antazoline Hydrochloride Betamethasone Cortisone Acetate Digoxin Lanatoside C Lysergic Acid Paramethasone Acetate Prednisone Acetate Amiloride Methylprednisolone Aminacrine... 

The photo-isomerisation of prednisone acetate (1) into "lumi-prednisone acetate (3) (Fig. 54 has commonly been represented as a single stage "cross-over process [42] but recent results [4g] suggest that the isomerisation is a multistage rearrangement analogous to those described above, and involving the ketones (22) and (23 as reactive intermediates. 

Potassium cyanide, 129 Pre-calciferol, 414, 417-418 Prednisone acetate, 191 —, photolysis, 425, 428-429 Pregnane side chain, conformations, 12, 139 —degradation, 344, 346 Pregnane skeleton, 2. 3 Product development control , X36, 139... 

A wide variety of complicated and strained structures has been obtained by irradiation of steroidal A -3-ketones and A 4-3 ketones [41]. Prednisone acetate (i) was reported in 1958 [42] to give the rearranged structure 2) by photolysis in aqueous acetic acid in a neutral solvent (ethanol) the product was lumiprednisone acetate (3) which underwent... 

Irradiation of prednisone acetate (129) in ethanol afforded the ketonic isomers 130 and 131, and in dioxane a phenolic isomer (Chart 22). 

Liang, Y., Li, J., Zhang, Z., and Zhang, X. Flow injection determination of prednisone acetate. Yaoiuu Penxi 7,azhi 18(3) 168-170, 1998. 

Treatment of a corticoid that bears the 4-en-3-one function with selenium dioxide abstracts hydrogen from ring A to introduce a new double bond to form a 1,4-dien-3-one. Application of this reagent to hydrocortisone acetate (4-4) results in the formation of prednisolone (6-1) (Scheme 7.6). The corresponding reaction on cortisone acetate (4-5) leads to prednisone acetate (6-2). 

Ferrosan Hostacortin NIsone NSC 10965 Prednisone acetate Prednisone 21-acetate U 6167. Glucocorticoid. Dec 228 232" [a]85= +186" (dioxane) Xm = 238 nm (c 16100 EtOH). Schering-Plough Healthcare Products. 

The conduct of a thermal microscopic study may be illustrated through the work conducted by Kuhnert-Brandstatter on the polymorphs and solvates of a series of steroid hormones [65]. For example, if Form II of corticosterone-21-acetate is preheated to I40°C on a hot stage, the solid is observed to melt at 145-148°C. Further heating of the system results in a solidification of the melt, to yield Form I, which then melts at 153-155°C. Similarly, Form II of prednisone acetate is isolated from most solvents and melts over the range of 225-228°C. With continued heating, the melt solidifies, and one observes the melting point of Form I at 232-241°C. 

Cortisone Acetate Deoxycortone Acetate Dexamethasone Dexamethasone Acetate Fludrocortisone Acetate Hydrocortisone Hydrocortisone Acetate Methylprednisolone Prednisolone Prednisolone Acetate Prednisone Prednisone Acetate... 

Methylpre dnisolone Prednisolone Dexamethasone Hydrocortisone Prednisone Prednisolone Acetate Hydrocortisone Acetate Fludrocortisone Acetate Prednisone Acetate Cortisone Acetate... 

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