Prednisone acetate, irradiation

Steroid Dienones. Steroids have proved useful tools in organic photochemistry as they have in so many other areas. Irradiation of prednisone acetate (Formula 47) in ethanol gives Formulas 48 and 49 rather than analogs of lumisantonin (Formula 29) (36). In dioxane solution prednisone acetate (Formula 47) gives the phenol (Formula 50). Irradi-... [Pg.336]

Formula 46) in the irradiation of the dienone (Formula 56) has also been shown to involve Formula 45 as an intermediate (35). The difference in the nature of the photochemical rearrangements of prednisone acetate (Formula 47) and santonin (Formula 28) appears to be associated with the absence of a 4-methyl group in prednisone acetate (see Secs. IIA,4 and IIA,7). [Pg.338]

A wide variety of complicated and strained structures has been obtained by irradiation of steroidal A -3-ketones and A 4-3 ketones [41]. Prednisone acetate (i) was reported in 1958 [42] to give the rearranged structure 2) by photolysis in aqueous acetic acid in a neutral solvent (ethanol) the product was lumiprednisone acetate (3) which underwent... [Pg.461]

Irradiation of prednisone acetate (129) in ethanol afforded the ketonic isomers 130 and 131, and in dioxane a phenolic isomer (Chart 22). [Pg.101]

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