Powder filling optimization formulation

Cables via the powder-in-tube (PIT) method The approach is especially suited to processing Bi-2223 into leads and cables for power applications. A silver or silver alloy tube, filled with the partially reacted precursor powders formulated to yield Bi-2223, is drawn down to a wire 1-2mm diameter. The wire is rolled into a tape if that is the required form, usually with a width-to-thickness ratio of approximately 10 1. The composite is then heated to 800-900 °C when the powder partially melts. The recrystallization process is controlled and the pure Bi-2223 phase develops with large grains oriented so that the Cu-O planes lie parallel to the silver surface to optimize Jc. 

The system provides an output package that includes a formulation (Table 5) with any necessary powder processing and filling conditions, the required capsule size, a statistical design to quantitatively optimize the formulation, specification of excipients used, recommended tests to validate the formulation, and a complete documentation of the decision process. 

The SDMT model has practical utility in aiding the rational optimization of the initial moisture contents of individual components in a system to attain the final desired relative humidity. Practical applications to date have included adjustment of the initial formulation LODs prior to capsule filling to avoid gelatin capsule brittleness, selecting the appropriate formulation moisture content and amount of desiccant to maintain the relative humidity inside a container below a defined value, and selection of appropriate dry powder inhaler design and packaging conditions for optimal stability. ... 

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