Posterior reversible leukoencephalopathy syndrome

Cerebral WM changes (WMC) are found in a number of diseases of adulthood, such as the debated Binswanger s disease, multiple sclerosis, acute demyelinating encephalomyelitis, posterior reversible leukoencephalopathy syndrome, cerebral anoxia, leukodystrophies, and mitochondrial encephalopathies, among others. The term leukoaraiosis (LA) is applied for nonspecific WMC, primarily in the elderly, that cannot be attributed to a... 

Reversible posterior leukoencephalopathy syndrome, in which imaging abnormalities are present in the parieto-occipital regions of the brain, is reversible after blood pressure control and withdrawal of epoetin (59,79). Monitoring of the blood pressure is indicated and the hematocrit should be increased slowly, with a target of not more than 30%. If hypertension and seizures are under control, epoetin therapy can be resumed (59). 

Utz, N., et al., MR imaging of acute intermittent porphyria mimicking reversible posterior leukoencephalopathy syndrome. Neuroradiology, 2001. 43(12) p. 1059-62. 

Edwards, M.J., et al.. Reversible posterior leukoencephalopathy syndrome following CHOP chemotherapy for diffuse large B-cell lymphoma. Ann Oncol, 2001.12(9) p. 1327-9. 

Xaylor, M.B., A. Jackson, and J.M. Weller, Dynamic susceptibility contrast enhanced MRI in reversible posterior leukoencephalopathy syndrome associated with haemolytic uraemic syndrome. Br J Radiol, 2000. 73(868) p. 438-42. 

Lewis, M.B., Cyclosporin neurotoxicity after chemotherapy. Cyclosporin causes reversible posterior leukoencephalopathy syndrome. BMJ, 1999. 319(7201) p. 54-5. 

Nervous system There have been rare reports in bevacizumab-treated patients of signs and symptoms that are consistent with reversible posterior leukoencephalopathy syndrome (RPLS), a rare neurological... 

Kaneda H, Okamoto I, Satoh T, Nakagawa K. Reversible posterior leukoencephalopathy syndrome and trastuzumab. Invest New Drugs... 

Ikeda, M., et al., Reversible posterior leukoencephalopathy in a patient with minimal-change nephrotic syndrome. Am J Kidney Dis, 2001. 37(4) p. E30. 

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