Possible Biological Significance

The majority of clinical isolates, in particular strains associated with L. pneumophila outbreaks, were found to bind mAb 2 and mAb 3/1. This has led to the notion that the 8-O-acetyl-associated epitope of legionaminic 

Glycosylation of the proteins has the potential to influence the interaction of the cell with its environment. The presence of negatively charged pseudaminic acid derivatives on the surface would lower the isoelectric point, influence solubility, and likely increase ionic interactions.15 In C. jejuni flagellin, these may be further controlled by introduction of a basic acetamidino group to the sugar.16 

---

A synthesis of possible biological significance was effected by Spath and Berger, who ozonised eugenol methyl ether to 3 4-dimethoxyphenyl-acetaldehyde (Villa), which was then condensed with 3 4-dimethoxy-phenylethylamine (Vlllb), and the resulting Schiff s base (IX) treated wit hot 19 per cent, hydrochloric acid, whereby it was transformed into... 

Many commercial lots of technical PCP are known to contain small — but possibly biologically significant — amounts of highly toxic dioxins, dibenzofurans, and hexachlorobenzene. These contaminants may be responsible for most of the toxicity of technical PCP preparations (McConnell et al. 1980 Parker et al. 1980 Wollesen et al. 1986 Holsapple et al. 1987). However, both technical-and analytical-grade PCP can induce hepatic mixed-function oxidases in intoxicated rats and cattle. In cattle, this effect was observed in both calves and adults, and in hepatic as well as pulmonary microsomes, and seemed to be dose related (Shull et al. 1986). 

Bonte F, Saunois A, Pinguet P, Meybeck A (1997) Existence of a lipid gradient in the upper stratum corneum and its possible biological significance. Arch Dermatol Res 289 78-92. 

Baas WJ, Naturally occurring r ct>-ring-A-triterpenoids and their possible biological significance, Phytochemistry 24 1875—1889, 1985. 

Linear furanocoumarins (psoralens) inhibit P450s as mechanism-based inactivators (suicide inhibitors). Thus, species that produce psoralens may have evolved C4H enzymes with enhanced tolerance to these compounds. Recombinant C4H from the psoralen-producing species R. graveolens showed markedly slower inhibition kinetics with psoralens, and possibly biologically significant tolerance, compared to C4H from a species that does not produce the compounds (H. tuberosus) ... 

Synthesis of a new molecular structure (new chemical entity or NCE) with possible biological significance. Discovery of a new pharmacologic action (e.g., the beta-blockers and the -antagonists). 

Woodhead, R.J, Law, R.J. and Matthiessen, P. (1999) Polycyclic aromatic hydrocarbons in surface sediments around England and Wales, and their possible biological significance. Marine Pollution Bulletin, 38, 773-790. 

Arnott, S., Fuller, W., Hodgson, A., Prutton, I. Molecular conformations and structure transitions of RNA complementary helices and their possible biological significance. Nature (Lond.) 220, 561-564 (1968)... 

Hikita, T, Tadano-Aritomi, K, lida-Tanaka, N, Levery, SB, Ishizuka, I and Hakomori, S (2002) Cationic glycosphingolipids in neuronal tissues and their possible biological significance. Neurochem Res, 27, 575-581. 

The possible biological significance of the amine oxidase systems has been discussed by Zeller. ... 

Waelsch in a recent review summarized his views on the possible biological significance of these transferases as follows ... 

A question which is invariably raised is that of the possible biological significance of active amines and polypeptides in the amphibian skin.At this early stage,an answer to this question seems premature.Before having more information on the occurrence of caerulein or oaerulein-like polypeptides in the skin of the different groups of amphibians any hypothesis on the function of the polypeptide would be futile. 

All the features of the reaction discovered by Brenner are analogous to the transpeptidation reaction proposed by Fruton. There is no information, at present, on the possible biological significance of this type of peptide synthesis via amino acid esters. 

Thus the heterogeneity of clupeine and iridine obtained from individual fish was confirmed, and it was concluded that heterogeneity is an intrinsic property of protamines. Its possible biological significance in the basic nuclear proteins, protamine and histone, seems to be of interest and importance but remains to be clarified (see Chap. X. C. 1). 

Martoja, R., Gouzerh, P., and Monniot, F. (1994) Cytochemical studies of vanadium, tunichromes and related substances in asddians possible biological significance. Oceanog. Mar. Biol. Anna. Rev., 32, 531-556. 

---