Polyvinyl alcohol sulphate

Pancreatic ribonuclease is markedly inhibited by heparinoids but not by mucopolysaccharides, with sulphated polyvinyl alcohol >sulphated corn amylosOsulphated cellulose > sulphated corn amylopectin> sulphated dextran, sulphated pectic acid, polyvinyl sulphonate with 2 T 7 per cent sulphur>sulphated nitro chitin, sulphated nitro chitosan and heparin . Single injections of heparin in mice result in significant inhibition of the acid alkaline ribonuclease of the liver after the injection. This probably explains the accumulation of ribonucleic acid in tissue culture cells in the presence of heparin. Heparin also inhibits rat acid phosphatase, glucuronidase , catalase , fumarase and elastase. 

Possible Effect of Charged End-groups. A possible reason for differences between samples might be the process used for polymerising the original polyvinyl acetate. Emulsion polymerisation is likely to introduce a proportion of ionic (sulphate or carboxyl) end-groups which would not be expected if bulk polymerisation with benzoyl peroxide had been used. An Antweller Microelectrophoresis apparatus was used to measure rates of electrophoresis of polyvinyl alcohols in solution in a pH 7.8 phosphate buffer. No significant difference was observed between... 

Sulphuric acid esters of tri- 8-hydroxyethyl-/J-propane tri-carboxylic acid ammonium (ThromboHolzinger), polyethylene sulphate sodium, polyanethol (liquoid), polyvinyl alcohol (elvanol), yeast nucleic acid, lignin, saponin, tannin, oromucoid, proteins... 

Polymerization is by free-radical-initiated reaction, in either suspension or emulsion processes in water at about SC C. In the suspension process, polyvinyl alcohol, incompletely hydrolysed PVAC, or gelatine, are used as a colloid stabilizer with peroxide initiators. The emulsion process employs emulsifiers, such as sodium lauryl sulphate and water-soluble persulphate initiators. Mass polymerization gives PVC powders with characteristics different from those of suspension polymer. 

A monomer phase is prepared by dissolving polyvinyl alcohol and sodium ethoxylated octyl phenol sulphate in the remaining water. The ethyl acrylate and methyl methacrylate monomers are added together with the sodium metabisulphite and the mixture stirred to form an emulsified monomer phase. 

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