Polysorbates oxidizing agents

Phenylethanol Antimicrobial preservative (not oral) Oxidizing agents, proteins, polysorbates... 

Incompatible with oxidizing agents and protein, e.g., serum. Phenylethyl alcohol is partially inactivated by polysorbates, although this is not as great as the reduction in antimicrobial activity that occurs with parabens and polysorbates. ... 

Precaution Wear safety glasses with side shields and robber or Neoprene gloves to prevent skin conlad avoid conlad with strong oxidizing agents, adds, or bases Storage Store away from heat or dited sunlight Jeesorb L-20 [Jeen Infl.j Chem. Descrip. Polysorbate 20... 

Storage Store in well-ventilated areas 50-120 F keep away from oxidizing agents, excessive heat, ignition sources Lumisorb PSMS-20 K [Lambent Tech j Chem. Descrip. Polysorbate 60 Ionic Nature Nonionic CAS 9005-67-8... 

Sorbitan fatty acid esters are produced by polymerization of ethylene oxide to sorbitan fatty acid esters. The resulting polyoxyethylene sorbitan esters are nonionic hydrophilic emulsifiers. They are used in bakery products as antistaling agents. They ate known as polysorbates with a number as indication of the type of fatty acid used (e.g., lauric, stearic, or oleic acid). 

Sulfhydryl compounds cause significant reductions in the activity of bronopol, and cysteine hydrochloride may be used as the deactivating agent in preservative efficacy tests lecithin/ polysorbate combinations are unsuitable for this purpose. Bronopol is incompatible with sodium thiosulfate, with sodium metabisulfite, and with amine oxide or protein hydrolysate surfactants. Owing to an incompatibility with aluminum, the use of aluminum in the packaging of products that contain bronopol should be avoided. 

Processes for adenovirus purification typically end with concentration, formulation, and sterile filtration operations [40, 80,106]. Concentration and formulation are usually carried out in ultra-filtration units equipped with 100-300-kDA membranes [40,106]. The exact composition of the formulation buffer will depend on the intended application, mode of administration (injectable, aerosol), and required short-term and shelf stability [104,123]. A typical liquid formulation may include an aqueous buffer supplemented with cryoprotectants (e.g., sucrose) and stabilizers such as the nonionic-surfactant polysorbate-80, the chelating agent EDTA, and the oxidation inhibitors ethanol and histidine [123]. Filtration under sterile conditions is typically performed with 0.22-pm membranes [103,106]. 

Commercial products are complex mixtures of partial esters of sorbitol and its mono- and di-anhydrides condensed with an approximate number of moles of ethylene oxide. The formula of a representative component is shown above. The polysorbates are miscible with water, as reflected in their higher HLB values (see Table 1.2), and are used as emulsifying agents for oil-in-water emulsions. 

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