Polysaccharides Streptococcus Group

There are solitary examples of other alditol phosphates as components of this class of polymers. Arabinitol 1-phosphate is part of the S. pneumoniae type 17F capsular polysaccharide. o-Glucitol 6-phosphate is a component of the group-specific polysaccharide from group B Streptococcus, which has a most unusual, ramified structure. In a polysaccharide from Nocardia... 

Leon and Young found that the specificity of anti-pneumococcal C myeloma immunoglobulins is for the phosphorylcholine or choline determinant of this antigen.72 Many other antigens, such as polysaccharides from groups O and H streptococcus,66 Ascaris,73 Lac-... 

Structure and Conformation of the Capsular Polysaccharides of Group B Streptococcus... 

Hyaluronan can be extracted from the tissue of vertebrate animals (Table 3.1) or from the bacteria that creates the protecting capsule from the polysaccharides. The best bacterial strain for such a purpose is the haemolytic Streptococcus groups A and B. 

In a study concerning the immunospecificity of the capsular polysaccharides of Streptococcus group B, type III, Jennings et al (1981) applied HC-NMR spectroscopy as a main tool for structure analysis. The native capsular polysaccharide consists of a backbone of -6)GlcNAc (l 3)Galp(l-4)Glcp(l-... 

A convergent synthesis has been reported for a hexasaccharide fragment of the Streptococcus group A cell-wall polysaccharide (Scheme 32) [125], The 3-0-unprotected rhamnose acceptor was first glycosylated with the A-phthaloyl-protected glucosamine trichloroacetimidate and then with a suitably protected... 

Many bacterial polysaccharides contain phosphoric ester groups. There is a limited number of examples of monoesters. More common are phosphoric diesters, connecting an amino alcohol or an alditol to the polysaccharide chain. Another possibility is that oligosaccharide or oligosaccharide-alditol repeating units are connected to a polymer by phosphoric diester linkages. In addition to the intracellular teichoic acids, several bacteria, for example, different types of Streptococcus pneumoniae, elaborate extracellular polymers of this type. These polymers are generally discussed in connection with the bacterial polysaccharides. 

DRPVPY mAb SA-3 Group A Streptococcus cell-wall polysaccharide [25]... 

Scheme 4 Structures of the Group A Streptococcus cell-wall polysaccharide, and of branched trisaccharide (1) and hexasaccharide (2) fragments recognized by antibodies...

Fig. 7 A model of the cell-wall polysaccharide (CWPS) of group A Streptococcus, looking down the barrel of the helix. The core of the helix is composed of a-L-rhamnose residnes with the 8-d-G1cNAc moieties displayed on the periphery. Reprodnced with permission from [99]. 2004 Elsevier Science...

By applying the NOESY step first, this experiment allows us to jump from one spin system to another or to overcome a bottleneck in TOCSY transfer caused by an occurrence of a small coupling constant in the chain of J-connectivities. Both these features are illustrated in ID NOESY-TOCSY spectra of the type VI group B Streptococcus capsular polysaccharide (1). 

Epimerization at C-2 of UDP-GlcNAc, leading to the UDP derivative of 2-acetamido-2-deoxy-D-mannose, was also observed115 118 the monosaccharide was identified as a constituent of several capsular polysaccharides from Streptococcus pneumonia119-122 and Neisseria meningitidis group A (Ref. 123), the teichuronic acid of Bacillus cereus,124 and the O-specific... 

---