Polymorphism discovery

A general approach to single-nucleotide 60 polymorphism discovery. Nat Genet 1999 23 452-456. 

A second variant detection strategy involves directed resequencing of selected genomic regions from different individuals, usually between 50 and 100 unrelated individuals. Many of these efforts have screened a subset of the DNA Polymorphism Discovery Resource collection, a set of 450 samples selected by the NIH to be a sample of the ethnic diversity of the U.S. popu-... 

Collins FS, Brooks LD, Chakravarti A. A DNA polymorphism discovery resource for research on human genetic variation. Genome Res 1998 8 1229-1231. 

Hart JR, Johnson MD, Barton JK. Single-nucleotide polymorphism discovery by targeted DNA photocleavage. Proc. Natl. Acad. Sci. U.S.A. 2004 101 14040-14044. 

Early stage solid-state analysis (polymorph discovery)... 

Polymorph discovery by solvent recrystallization is based on the principle that the less stable forms recrystallize before the more stable ones. This is often referred to as Ostwald s law of stages [13]. As the system progresses from the liquid to the solid state, it will go to the state nearest in free energy to that of the liquid state. Frequently a metastable crystal form will appear and then convert to... 

Blazej, R.G, Paegel, B.M., and Mathies, R.A., Polymorphism ratio sequencing A new approach for single nucleotide polymorphism discovery and genotyping. Genome Res., 13, 287, 2003. 

FIT probes peptide nucleic acid probes with a fluorescent base surrogate enable real-time DNA quantification and single nucleotide polymorphism discovery. Anal Biochem., 375, 318-330. 

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