Genomic selectivity

Lin, J. C., Smith, M. C., and Pagano, J. S. (1983) Activation of latent Epstein-Barr virus genomes selective stimulation of synthesis of chromosomal proteins by a tumor promoter. J. Virol. 45, 985-991. 

SONESSON A K and 0degArd j (2012) Mating stractures for genomic selection breeding programs in aquaculture (Submitted). 

SONESSON A K, GODDARD M E and MEUWissEN THE (2010) The use of communal rearing of families and DNA pooling in aquaculture genomic selection schemes , Genetic Selection Evolution, vol. 42, no. 1, p. 41. 

It is likely that ara-HxMP similarly exerts its antiviral activity in the form of the triphosphate, ara-HxTP, since ara-HxTP inhibits HSV-1 DNA polymerase (49). Another possible explanation of the antiviral activity of ara-HxTP is that it is metaboHcaHy converted to ara-AMP. In fact, it has been shown at Wellcome Research Laboratories that ara-HxMP is a substrate for adenylosuccinate synthetase, and that the resulting arabinofuranosyladenylosuccinate is cleaved to ara-AMP by adenylosuccinate lyase (1). The selective action of ara-A against HSV appears to be a consequence of the preferential inhibition of ara-ATP against HSV-1 and HSV-2 polymerases. Ara-ATP also inhibits normal cellular DNA polymerases, which may be the reason for its cellular toxicity. Also, it has been observed that ara-A is incorporated uniformly throughout the HSV-1 genome, which may result in defective viral DNA (50). 

Interestingly, the genomic sequences of all AMPA receptor subunits contain a Q codon for this position and the R codon is selectively introduced into the GluR-B pre-mRNA by RNA editing [3]. Additionally, the Q/R site is a critical determinant of current... 

Upon screening genomic libraries obtained from environmental samples, more than 200 new nitrilases that allow mild and selective hydrolysis of nitriles were discovered [56]. One of them catalyzes the (R)-selective hydrolysis of (16) with a value... 

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