Polymer brushes molecularly imprinted

Brush-type, proteins, CDs, natural molecular imprint-based polymers (MIP), and macrocyclic antibiotics have been immobilized as chiral selectors on packed-CEC columns. Zheng and Shamsi demonstrated the possibility of using chiral CEC—ESI/MS with a commercially packed column for the determination of warfarin enantiomers in human plasma using coumachlor as an internal standard (IS). Robustness of this chiral CEC capillary was recently improved by a novel procedure and applied for the simultaneous enantiosepara-tion of height /1-blockers with multimodal CSP using different combinations of vancomycin and teicoplanin, as presented in Figure 5. ... 

Patel, A.K. Sharma, P.S. Prasad, B.B. (2009). Electrochemical sensor for uric acid based on a molecularly imprinted polymer brush grafted to tetraethoxysilane derived sol-gel thin film graphite electrode. Materials Science and Engineering C, 29,1545-1553. 

Pan, G., Zhang, Y, Guo, X., Li, C., and Zhang, H. 2010. An efficient approach to obtaining water-compatible and stimuli-responsive molecularly imprinted polymers by the facile surface-grafting of fimctional polymer brushes via RAFT polymerization. Biosensors and Bioelectronics 26 976-82. 

Besides the typical syntheses of polymer brushes from flat, low-area substrates, STIMP can be conducted from cellulose membranes, carbon nanotubes, and silica or polymeric beads, which has allowed Sl-lMP to be used for synthesis of molecularly imprinted polymers (MIPs) from a variety of supports [76-80]. The use of SI-IMP to fabricate MIPs is particularly advantageous over more common fabrication of MIPs by surface-initiated polymerization from surface-bound conventional initiators because the dithiocarbamyl radicals generated from surface-bound iniferters do not cause polymerization in solution, resulting in improved separation capacity [76-80]. In this section a few examples of fabrication of MIPs synthesized by STIMP from a variety of supports for molecular recognition or separation applications are briefly summarized with a focus on particular advantages enabled by the STIMP method. 

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