Polyketides and nonribosomal peptides

Fischbach, M.A. and Walsh, C.T. (2006) Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics logic, machinery, and mechanisms. Chemical Reviews, 106, 3468—3496. [Pg.78]

Staunton, J. and Wilkinson, B. (2001) Combinatorial biosynthesis of polyketides and nonribosomal peptides. Current Opinion in Chemical Biology, 5, 159. [Pg.257]

Walsh, C.T. (2004) Polyketide and nonribosomal peptide antibiotics modularity and versatility. Science, 303, 1805. [Pg.257]

Kopp, F. and Marahiel, M.A. (2007) Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Natural Product Reports, 24, 735. [Pg.259]

Posttranslational modifications can be broken down into two main classes those that are reversible and those that are irreversible. Included in the large group of reversible posttranslational modifications are phosphorylation, acetylation, and disulfide formation. Irreversible posttranslational modifications include peptide bond cleavage as in intein splicing also irreversible is the introduction of a phosphopantetheinyl group during fatty acid, polyketide, and nonribosomal peptide biosyntheses. The current debate is whether to classify lysine N-methylation as reversible or irreversible. Recently, there have been reports of lysine demethylases. ... [Pg.434]

Carreras CW, Pieper R, Khosla C (1997) The Chemistry and Biology of Fatty Acid, Polyketide, and Nonribosomal Peptide Biosynthesis. 188 85-126 Ceulemans A (1994) The Doublet States in Chromium (III) Complexes. A Shell-Theoretic View. 171 27-68... [Pg.244]

CT Walsh, AM Gehring, PH Weinreb, EN Luis, RS Flugel. Post-translational modification of polyketide and nonribosomal peptide synthetases. Curr Opin Chem Biol 1 309-315, 1997. [Pg.36]

A final example of metabolic pathway engineering is based on polyketide and nonribosomal peptide biosynthesis. Polyketides and nonribosomal peptides are complex natural products with numerous chiral centers, which are of substantial economic benefit as pharmaceuticals. These natural products function as antibiotics [erythromycin A (65), vancomycin (66)], antifungals (rapamycin, amphotericin B), antiparasitics [avermectin Ala (67)], antitumor agents [epothiolone A (68), calicheamicin yj, and immunosuppressants [FK506 (69), cyclosporin A], Because this exponentially growing and intensely researched field has developed, the reader is directed to review articles for additional details.347-359 Also with the potential economic benefit to develop the next blockbuster pharmaceutical, a number of patents and patent applications have been published.360-366... [Pg.387]

Because these genes are often arranged in clusters, this has allowed a combinatorial biosynthetic approach for the construction of diverse libraries of polyketides and nonribosomal peptides.388387 The use of E. coli as a production host whereby precursor supply and selected pathway enzymes are modified has resulted in respectable titers of targeted compounds as well as novel derivatives.388393... [Pg.390]

Despite these complex biochemical systems, much progress has been made to understand and manipulate them at the genetic level. This will ultimately lead to the generation of novel products, which, on screening against selected targets, might allow new polyketides and nonribosomal peptides to be identified with enhanced pharmaceutical properties. [Pg.390]

The Chemistry and Biology of Fatty Add. Polyketide, and Nonribosomal Peptide Biosynthesis... [Pg.87]

Polyketide and nonribosomal peptide synthetases resemble fatty acid synthase Section 22,4.10... [Pg.22]

Variations on a Theme Polyketide and Nonribosomal Peptide Synthetases Resemble Fatty Acid Synthase... [Pg.924]

The emphasis of this review is placed on two structural classes of natural products polyketides and nonribosomal peptides (NRPs). The MS of these biosynthetic pathways is most advanced and will be covered in detail. In the following sections we will describe the current methods and applications used to study the biosynthetic pathways of natural products and provide a glimpse into upcoming techniques. In addition, a brief introduction to experimental design using high-end MS to study the biosynthesis of other natural metabolites, such as ribosomally encoded pathways and cofactors, is described. [Pg.390]

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