Polyhydroxyalkanoates modification

Hazer, B., and Steinbtichel, A. (2007) Increased diversification of polyhydroxyalkanoates by modification reactions for industrial and medical applications. Appl. Microbiol. Biotechnol., 74, 1-12. 

Gerngross, T.U., Snell, K.D., Peoples, O.P., Sinskey, A.J., Csuhai, E., Masamune, S., and Stubbe, J. (1994) Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus evidence for a required posttranslational modification for catalytic activity. Biochemistry, 33, 9311-9320. 

Zinn, M., Hanry, R. Tailored material properties of polyhydroxyalkanoates through biosynthesis and chemical modification. Adv. Eng. Mater. 7, 408—441 (2005)... 

Kim DY, Kim HW, Chung MG, Rhee YA (2007) Biosynthesis, modification, and biodegradation of bacterial medium-chain-length polyhydroxyalkanoates. J Microbiol 45 87-97 Kominek LA, Halvorson HO (1965) Metabolism of poly-beta-hydroxybutyrate and acetoin in Bacillus cereus. J Bacteriol 90 1251-1259... 

Choddk I., Polyhydroxyalkanoates Properties and modification for high volume apphcations, in Degradable Polymers, Principles and Applications, Ed. Scott G., 2nd Edition, Kluwer Academic Publishers, Dordrecht/Boston/London, 2002, p. 295. Chambers R., Daly J.H., Hayward D., liggat J.J., J. Mater. Sci., 36,2001,3785-3792. 

There is at present much interest in developing new polymers from plant sources, often using fermentation techniques or genetic modification. Polyhydroxyalkanoates... 

Chodak I (2002) Polyhydroxyalkanoates properties and modification for high volume applications. In Scott G, editor. Degradable polymers - principles and applications. Dordrecht/Boston/London Kluwer Academic Publishers, pp. 295-319. 

A common route that can be applied for obtaining polyhydroxyalkanoates with desirable functionalities is to produce PHAs with terminal double bonds followed by chemical modification steps. Carbon double bonds are comparatively inert but can be easily transformed into reactive functional groups under mild reaction conditions. Non-functionalized PHAs can also be activated by surface modification techniques. The resulting tailor-made structural and material properties have positioned polyhydroxyalkanoates well to contribute to the manufacturing of second and third generation biomaterials. ... 

Kang IK, Choi SFI, Shin DS, Yoon SC. Surface modification of polyhydroxyalkanoate films and their interaction with human fibroblasts. Int J Biol Macromol 2001 ... 

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