Polychlorinated biphenyls immunotoxicity

Silkworth JB, Grabstein EM. 1982. Polychlorinated biphenyl immunotoxicity Dependence on isomer planarity and the Ah gene complex. Toxicol Appl Pharmacol 65 109-115. 

Davis D, Safe S. 1989. Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Lett 48 35-43. 

Harper N, Connor K, Safe S. 1993a. Immunotoxic potencies of polychlorinated biphenyl (PCB), dibenzofuran (PCDF) and dibenzo-/ -dioxin (PCDD) congeners in C57BL/6 and DBA/2 mice. 

Tryphonas H. 1994. Immunotoxicity of polychlorinated biphenyls Present status and future considerations. Exp Clin Immunogenet 11 149-162. 

Polychlorinated biphenyls, PCBs, are among the most hazardous human-made substances, distributed so widely that they have been classified as global POPs. They comprise a group of 209 structurally similar compounds, so called congeners, with diverse teratogenic, reproductive, immunotoxic, neurotoxic and carcinogenic effects. 

Dioxins are prominent members of the class of polychlorinated hydrocarbons that also includes diben-zofuran, biphenyls and others. Dioxins are highly toxic environmental contaminants. Like others small planar xenobiotics, some dioxins bind with high affinity to the arylhydrocarbon (Ah) receptor. Dioxins activate the receptor over a long time period, but are themselves poor substrates for the enzymes which are induced via the Ah-receptor. These properties of the dioxins and related xenobiotics may be important for the toxicity of these compounds. Dioxins like 2,3,7,8-tetrachloro-p-dibenzodioxin can cause persistent dermatosis, like chloracne and may have other neurotoxic, immunotoxic and carcinogenic effects. 

Although drugs such as acetaminophen bind to AhR, the majority of AhR agonists or antagonists are environmental chemicals. Polychlorinated diben-zodioxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dibenzofu-rans, biphenyls, and a number of other chemicals are widespread pollutants in aquatic ecosystems. These compounds cause a high reproductive and developmental toxicity, which is mediated via binding to the AhR. Thus they pose a serious threat to many populations of mammals, birds, and fish. Various adverse effects—including structural malformations, reduced fertility, tumor promotion, immunotoxicity, and skin disorders like chloracne—have been observed [139]. 

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