Dendrimer polyamidoamine

Keywords. Polyamidoamine dendrimers. Activation of PAMAM dendrimers. Transfection, Gene transfer, DNA-dendrimer complex... 

Recently, highly branched macromolecular polyamidoamine dendrimers have been prepared with Co11 bound where the metal ions have additional exchangeable coordination sites.450 These macromolecules show a capacity for catalyzing the hydrolysis of phosphate esters, presumably via intermediate bound phosphoester species. 

Kukowska-Latallo JF, Bielinska AU, Johnson J, Spindler R, Tomalia DA, Baker JR Jr (1996) Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proc Natl Acad Sci USA 93 4897 -902... 

L. Shen and N.F. Hu, Heme protein films with polyamidoamine dendrimer direct electrochemistry and electrocatalysis. BBA-Bioenergetics 1608, 23—33 (2004). 

Tomalia, D. A. and Dvornic, P. R. Dendritic polymers, divergent synthesis (starburst polyamidoamine dendrimers) , in Salamone, J. C. (ed.), Polymeric Materials Encyclopedia, Vol. 3, CRC Press, Boca Raton, FL, 1996, pp. 1814-1830. 

Arima, H., F. Kihara, F. Hirayama, and K. Uekama. 2001. Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins. Bioconjug Chem 12(4) 476-84. 

O. Ozturk, et ah, Thermal decomposition of generation-4 polyamidoamine dendrimer films decomposition catalyzed by dendrimer-encapsulated R particles, Langmuir 21, 3998-4006 (2005). 

I,ee 1, Athey BD, Wetzel AW, Meixner W, Baker JR Jr. Stmctural molecular dynamics studies on polyamidoamine dendrimers for a therapeutic application effects of pH and generation. Macromolecules 2002 35 4510-4520. 

Polyamidoamine Dendrimer, primary amino In vitro and in vivo (Haensler and Szoka, 1993 ... 

Bielinska, A.U., Kukowska-Latallo, J.F. and Baker, Jr., J.R. (1997) The interaction of plasmid DNA with polyamidoamine dendrimers mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA. Biochim. Biophys. Acta., 1353,180-190. 

Hudde, T., Rayner, S.A., Comer, R.M., Weber, M., Isaacs, J.D., Waldmann, H., Larkin, D.F.P. and George, A.J.T. (1999) Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium. Gene Ther., 6, 939-943. 

Tang, M.X., Redemann, C.T. and Szoka, F.C. (1996) In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug. Chem., 7, 703-714. 

Malik, N., et al. 2000. Dendrimers Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 1251-labelled polyamidoamine dendrimers in vivo. 

Fludde, T., et al. 1999. Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium. Gene Ther 6 939. 

Dennig J, Duncan E (2002) Gene transfer into eukaryotic cells using activated polyamidoamine dendrimers. J Biotechnol 90(3 4) 339—347... 

Synthetic polymer. Among the cationic synthetic polymers used for gene delivery are polyethylenimine (PEI), polyamidoamine dendrimers, and poly(2-dimethylaminoethyl methacrylate).161-164 Depending on the flexibility (or rigidity) of the polymers, they form either a small (<100 nm) DNA polyplex or a large (>1 to 10 pm) DNA polyplex.165 More detailed physicochemical properties and their transfection efficacy are to be discussed. 

On-chip chiral separation of enantiomers of adrenaline, noradrenaline, and dopamine was achieved using a mixture of carboxymethyl-p-cyclodextrin (CMCD) and a polyamidoamine dendrimer (Starburst) [120], On-chip chiral separation of enantiomers of homovanillic acid, DOPA, cDOPA, methoxy-tyramine (MT), metanephrine, and normetanephrine was achieved using a mixture of 18-crown-6-ether and carboxymethyl-P-cyclodextrin [120],... 

Fig. 1 Polyamidoamine dendrimers. The heteroatoms omitted from G4 - OH for clarity...

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