Poly glycolide-co-trimethylene carbonate

Poly(glycolide-co trimethylene carbonate). Another successful approach to obtaining an absorbable polymer capable of producing flexible monofilaments has involved finding a new type of monomer for copolymerization with glycoHde (42). Trimethylene carbonate polymerized with glycoHde is shown below ... 

Abbreviations DLPLA. poly (D. L-lactide) DLPLG, poly (D, L-lactide-co-glycolide) LPLA, poly (L-lactide) PCL, poly (caprolactone) PDO, poly (dioxanone) PGA, poly (glycolide) FGA-TMC. poly (glycolide-co-trimethylene carbonate). 

Owing to its hydrolytic instability, initially, its use was limited. Currently, polyglycolide and its copolymers poly(lactic-co-glycolic acid) with lactic acid, poly(glycolide-co-caprolactone) with e-caprolactone, and poly(glycolide-co-trimethylene carbonate) with trimethylene carbonate) are widely used to develop synthetic absorbable sutures that were marketed under the trade name of Dexon and are now sold as Surgicryl [61],... 

A resorbable biotextile is a temporary supporting material in the human body its objective is to restore or repair the function of diseased or traumatized tissue. Several kinds of resorbable polymers are used for biotextUe applications. In suture application, glycolic and lactic add polymers are commercially used. Poly(glycolide-co-trimethylene carbonate), poly(glycolide-co-lactide-co-trimethylene carbonate), polydioxanone (Bourne, 1988), poly(lactide-co-caprolactone) (Tomihata, 1998) and polyhydroxyalkanoate (Voloka, 2003) have also been investigated for use as sutures. Natural polymers, such as chitin, chitosan and a benzyl ester of hyaluronic acid are... 

Poly(glycolide-co-trimethylene carbonate-co-e-caprolactone) copolymer (Monosyn )... 

Poly(glycolide-co-trimethylene carbonate) COVIDIEN Maxon 1985 180-210 days... 

Copolymers of PLA and PGA tend to be less crystalline and less hydrophobic than the homopolymer and subsequently have shorter degradation times. Poly(lactide-co-glycolide) (PLGA) has been used extensively for drug delivery and device manufacture." Copolymers of glycolide with trimethylene carbonate (TMC), called polyglyconate, have been used as sutures (Maxon ) and as screws." ... 

Han, Y.R., Jin, X.Y., Yang, J., Fan, Z.Y., Lu, Z.Q., Zhang, Y., Li, S.M., 2012b. Totally bioresorbable composites prepared from poly(L-lactide)-co-(trimethylene carbonate) copolymers and poly(L-lactide)-co-(glycolide) fibers as cardiovascular stent material. Polymer Engineering Science 52, 741—750. 

These representative aliphatic polyesters are often used in copolymerized form in various combinations, for example, poly(lactide-co-glycolide) (PLGA) [66-68] and poly(lactide-co-caprolactone) [69-73], to improve degradation rates, mechanical properties, processability, and solubility by reducing crystallinity. Other monomers such as 1,4-dioxepan-5-one (DXO) [74—76], 1,4-dioxane-2-one [77], and trimethylene carbonate (TMC) [28] (Fig. 2) have also been used as comonomers to improve the hydrophobicity of the aliphatic polyesters as well as their degradability and mechanical properties. 

Dong, J., Liao, L., Ma, Y., Shi, L., Wang, G.X., Fan, Z., Li, S., Lu, Z., 2014a. Enzyme-catalyzed degradation behavior of L-lactide/trimethylene carbonate/glycolide terpolymers and a composite with poly(L-lactide-co-glycolide) fibers. Polymer Degradation and Stability 103, 26-34. 

Trimethylene carbonate, TMC, is a commonly used co-monomer for poly(glycolide-c -lactide) base sutures [57,58]. Incorporation of the carbonate structure provides flexibility and toughness to the otherwise rigid and brittle copolyesters. 

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