Poly administration routes

J. M. Irache, M. Berrabah, P. Verite, and S. Menager, Phenobarbitone-loaded poly-curly epsilon-caprolactone nanocapsules In vitro kinetics and in vivo behaviour by the oral route, in Formulation of Poorly-Available Drugs for Oral Administration, Paris, 1996, pp. 334-337. 

Recently, Damge et al. showed that the incorporation of octreotide, a somatostatin analogue, in poly(alkylcyanoacrylate) nanocapsules also improved and prolonged the therapeutic effect of this peptide, after administration by the oral route. 

Like clotrimazole, miconazole was originally developed as an intravenous and oral antifungal agent. The intravenous formulation was discontinued due to anaphylactic reactions associated with the injection vehicle excipient, poly-oxyl 35 Castor Oil (Cremophor EL), used to enhance the solubility of miconazole. Unlike clotrimazole, repeated administration does not induce the hepatic microsomal enzymes involved in its own metabolism. Following oral administration, around 20% of a dose is systemically absorbed where it undergoes oxidadve O-dealkylation and oxidative N-dealkylation prior to excredon (Fig. 24.5). Approximately 40% of the administered dose is excreted unchanged in the faeces. The faecal route of excredon for... 

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