Plus secondary amine

Tertiary amines determination of primary plus secondary amines... 

Ethoxylated (3) N-tallow-1,3-diarainopropane TSCA Number 61790-85-0 Equivalent Weight Min. 220/Max. 250 Primary plus Secondary Amine, % Max. 2... 

The 1,4-isomer has been similarly generated from terephthalonitdle [623-26-7] (56) using a mixed Pd/Ru catalyst and ammonia plus solvent at 125 °C and 10 MPa (100 atm). It is also potentially derived (57) from terephthaUc acid [100-21-0] by amination of 1,4-cyclohexanedimethanol (30) [105-08-8], Endocyclization, however, competes favorably and results in formation of the secondary amine (31) 3-a2abicyclo[3.2.2]nonane [283-24-9] upon diol reaction with ammonia over dehydration and dehydrogenation catalysts (58) ... 

An interesting preparation of substituted o-aminophenols has been developed by Birkofer and Daum (30). 2-Acylfurans (8) plus an aliphatic secondary amine presumably condense to give the eorresponding enamine (9) (not isolated), which undergoes thermal isomerization to the o-amino-phenol (10). 

The only kinetic data reported are in a Ph.D. thesis (41). Integral order kinetics were usually not obtained for the reaction of a number of ketones with piperidine and a number of secondary amines with cyclohexanone. A few of the combinations studied (cyclopentanone plus piperidine, pyrrolidine, and 4-methylpiperidine, and N-methylpiperazine plus cyclohexanone) gave reactions which were close to first-order in each reactant. Relative rates were based on the time at which a 50% yield of water was evolved. For the cyclohexanone-piperidine system the half-time (txn) for the 3 1 ratio was 124 min and for the 1 3 ratio 121 min. It appears that an... 

In their study Roeda and Crouzel shower that the LAH reduction of nC02 produced 34% H11CHO plus 59% H11COOH. Our experience in using a mixture of DCHO and DCOOH for the N-methylation of both primary and secondary amines suggests that the corresponding [11C]-mixture would be ideal for the 11C-labeling of amines under microwave-enhanced conditions. 

This process is similar to the formation of an ester by the action of an acid anhydride on an alcohol (described in the earlier section Acid anhydride plus an alcohol ). Half the acid anhydride forms the amide the other half is a leaving group. Ammonia, primary amines, and secondary amines react to produce amides. Figure 12-27 shows the industrial preparation of phenacetin by the reaction of an amine with an acid anhydride. The mechanism for this reaction is similar to the mechanism for the reaction of an acid chloride with an amine (refer to Figure 12-26). 

This antidepressant can interact with other drugs via its two mechanisms of action serotonin and NE uptake inhibition. The former action means that the same pharmacodynamic interactions will occur with venlafaxine as with SSRIs, including the serotonin syndrome. At higher doses, venlafaxine is also prone to the same pharmacodynamic interactions as NSRIs such as secondary amine TCAs like desipramine and with newer NSRIs such reboxetine. Thus, the combination of high-dose venlafaxine plus an MAOl could produce a hypertensive crisis as well as the serotonin syndrome. 

Secondary amines react (1) with nitrous acid, yielding nilrosamines, yellow oily liquids, volatile in steam, soluble in ether. The secondary amine may be recovered by heating the nitrosamine with concentrated HO, or hydrazines may be formed by reduction of the nilrosamines, eg., methylamline from methylphenylnitrosamine, (i 1 i C. 11 )N 0. reduction yielding unsymmetrical methylphenylhy-drazine, CHjtCni )NHNH , (2) with acetyl or benzoyl chloride, yielding substituted amides, thus, diethylamine plus acetyl chloride to form. V A -diethylacetamide (C lio NOCCH . (3) with benzene sulfonyl chloride, yielding substituted benzene sulfonamides, thus, diethylamine reacts to form N. A -diethylbenzenesulfonamide. Cf,H. lSO>N( C/thJ) . insoluble in NaOH. 

Tertiary amines do not react with nitrous acid, acetyl chloride, benzoyl chloride, benzenesulfonyl chloride, but react with alkyl halides to form quaternary ammonium halides, which are converted by silver hydroxide to quaternary ammonium hydroxides. Quaternary ammonium hydroxides upon heating yield (1) tertiary amine pins alcohol (or, for higher members, olefin plus water). Tertiary amines may also be formed (2) by alkylation of secondary amines, e.g., by dimethyl sulfate, (3) from amino acids by living organisms, e g, decomposition of fish in the case of trimethylamine. 

It might have been expected that N-glycosides derived from secondary amines (pyrimidine nucleosides) would resemble true glycosides ( O-glycosides ) in their behavior toward acids. (Moreover, 1-D-glucosylurea is hydrolyzed to D-glucose plus urea when refluxed with dilute sulfuric acid.270) The resistance of 1-glycosylpyrimi-... 

In the second step of the synthesis, amine plus formaldehyde gives an imine, present as its protonated iminium form, which gets reduced. Formaldehyde is so reactive that it reacts again with the secondary amine to give an iminium ion again, this is reduced to the amine. 

Ocfentanil is an opioid painkiller that lacks the addictive properties of morphine, Disconnection of the amide gives a secondary amine that we can convert to an imine for disconnection to a ketone plus 2-fluoro aniline. 

In benzene or DMF solution, primary and secondary amines having an a-CH react with Fe porphyrins to give bis(amine) adducts of Fe porphyrins, plus one mole of the corresponding imine (equation 47) " " ... 

Class II Other liquids composed of molecules containing both active hydrogen atoms and donor atoms (oxygen, nitrogen, and fluorine)—e.g., alcohols, acids, phenols, primary and secondary amines, oximes, nitro compounds with alpha-hydrogen atoms, nitriles with alpha hydrogen atoms, ammonia, hydrazine, HF, HCN (plus nitromethane, acetonitrile even though these form 3-dimensional networks they have weaker bonds than —OH and —NH bonds in class I)... 

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