Rhabdomyosarcoma pleomorphic

Okada DH, Rowland JB, Petrovic LM. Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy. Gynecol Oncol 1999 75(3) 509-13. 

KER, keratin, detected by a mixture of CAMS.2, MAK-6, and AEl /AE3 EMA, epithelial membrane antigen VIM, vimentin DES, desmin MSA, muscle-specific actin SMA, smooth muscle (alpha isoform) actin CALD, h-caldesmon S-1 OOP, S-100 protein LM, laminin UL, Ulex europaeus I lectin binding OCN, osteocalcin PRMS, pleomorphic rhabdomyosarcoma PLPS/DLPS, pleomorphic and dedifferentiated liposarcoma PLMS/DLMS, pleomorphic and dedifferentiated leiomyosarcoma MPNST, pleomorphic malignant peripheral nerve sheath tumor MFH, malignant fibrous histiocytoma DCHOR, dedifferentiated chordoma DCHS, dedifferentiated chondrosarcoma POCS, pleomorphic osteosarcoma. 

Soft tissue sarcomas with a potentially pleomorphic histologic appearance (Fig. 4.28 see Table 4.7) include so-called MFH (undifferentiated pleomorphic sarcoma), pleomorphic rhabdomyosarcoma, pleomorphic or dedifferentiated liposarcoma, dedifferentiated LMS, and pleomorphic MPNST. 

FIGURE 4.30 Pleomorphic rhabdomyosarcoma, shown here, is often indistinguishable from MFH on conventional morphologic studies. 

Gaffney EF, Dervan PA, Fletcher CD. Pleomorphic rhabdomyosarcoma in adulthood Analysis of 11 cases with definition of diagnostic criteria. Am J Surg Pathol. 1993 17 601-609. 

FIGURE 4.12 Desmin reactivity is a consistent feature in all histologic subtypes of rhabdomyosarcoma, including embryonal (A) alveolar (B) and pleomorphic (C) forms. 

Kodet R, Newton Jr WA, Hamoudi AB, et al. Childhood rhabdomyosarcoma with anaplastic (pleomorphic) features. A report of the Intergroup Rhabdomyosarcoma Study. Am J Surg Pathol. 1993 17 443-453. 

Pleomorphic or anaplastic rhabdomyosarcoma, a rare adult variant of rhabdomyosarcoma. 

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