Clusters amino acids

Controllable Assembly, Structures, and Properties of Lanthanide-Transition Metal-Amino Acid Clusters... 

Abstract Amino acids are the basic building blocks in the chemistry of life. This chapter describes the controllable assembly, structures and properties of lathanide(III)-transition metal-amino acid clusters developed recently by our group. The effects on the assembly of several factors of influence, such as presence of a secondary ligand, lanthanides, crystallization conditions, the ratio of metal ions to amino acids, and transition metal ions have been expounded. The dynamic balance of metalloligands and the substitution of weak coordination bonds account for the occurrence of diverse structures in this series of compounds. 

In the following sections, our work on the amino acid clusters will be reviewed according to the effects of the various reaction conditions on self-assembly. 

Except for the factors mentioned above, such as the reactant ratio employed, variation of lanthanide and transition metal, crystallization conditions, and the presence of a secondary ligand, there are several other factors that can affect the controllable assembly of the lanthanide-transition metal-amino acid cluster compounds. 

Takats, Z. Nanita, S. C. Cooks, R. G. Schlosser, G. Vekey, K. Amino Acid Clusters Formed by Sonic Spray Ionization. Anal Chem. 2003a, 75, 1514-1523. 

Another characteristic of the secondary structure of protein includes the occurrence of hydrophobic amino acids clustered on the surface of globular proteins. It seems that hydrophobic amino acids occur regularly as the 20th amino acid in the primary structure of the peptide. These amino acids are rotated on an angle of 100° on the axis of the protein such that the globular proteins have all hydrophobic amino acids clustered to one side on the helical surface of protein, whereas the other end of the globular protein contains polar amino acids. Thus, it is possible to generate a wheel of amino acids in a protein in which the hydrophobic amino acids are clustered on one side of the helix, and the other side contains polar amino acids. 

Heparin BP HBPs Basic amino acid clusters Heparin and heparin sulfate ... 

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