Mitochondria dysfunction

D-MS Gentamicin Rat kidney 20 proteins IDed mitochondria dysfunction in renal cortex... 

Kim, G.J., et al. DNA damage and mitochondria dysfunction in cell apoptosis induced by nonthermal air plasma. Applied Physics Letters 96(2), 021502 (2010)... 

Several oxPC species, such as PGPC, PONPC, and PAzPC, were shown to induce mitochondria dysfunction and promote apopotic cell death. Endogenonsly produced or internalized via the TMEM30a transporter, truncated oxPC can directly intercalate into the mitochondria manbrane and thus induce mitochondria membrane depolarization, swelling, and mitochondria permeability transition (MPT) pore... 

Mitochondria play a central role in response to apoptotic stimuli. There is increasing evidence that altered mitochondrial function is linked to apoptosis and a decreasing mitochondrial transmembrane potential ( Pm) is associated with mitochondria dysfunction. The MPT (mitochondria permeability transition) is a permeability increase of the mitochondria membrane coupled with depolarization of the membrane and disruption of mitochondrial membrane integrity. We measured A Pm using a fluorescent probe DiOC6(3) which specially accumulated in polarized membranes and was monitored by flow... 

Begriche K, Igoudjil A, Pessayre D, Fromenty B. Mitochondrial dysfunction in NASH Causes, consequences and possible means to prevent it. Mitochondrion. 

Dagan T., C. Sable, J. Bray, and M. Gerschenson. 2002. Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities What is the evidence Mitochondrion 1 397 12. 

It should not be assumed that hydroxy fatty acids are biologically inactive. Hydroxy fatty acids are chemotactic and vasoactive. Such fatty acids could perturb phospholipids in membranes. For instance, cardiolipin containing hydroxy-linoleic acid does not support the electron transport coupled to ATP production of the mitochondrion. 5-Hydroxy de-canoic acid is a well-known inhibitor of the K -ATP channel. Isoprostanes, trihydroxy oxidation products of arachi-donic acid, are vasoconstrictors (76). 13-Hydroxy linoleic acid (13-HODE) is a lipoxygenase-derived metabolite that influences the thromboresistant properties of endothelial cells in culture (77). However, there is some doubt about the tme nature of these hydroxy-fatty acids generated by the cells, as there are several GSH- and NADPH-dependent pathways that can immediately reduce hydroperoxy- to hydroxy-fatty acids. Furthermore, the reduction step of the analytical method would have converted the hydroperoxy- to a hydroxy-group. Nevertheless, much work remains to be done to determine the relative contribution of hydroperoxy- and hydroxy- to the biological effects of fried fat, and in particular their role in endothelial dysfunction and activation of factor VII. There have been earlier suggestions that a diet rich in lipid peroxidation products may lead to atherosclerosis and CHD (34,78). 

G. Chen, F. Wang, D. Trachootham, and P. Huang, Preferential killing of eancer cells with mitochondrial dysfunction by natural compoimd s. Mitochondrion, 10 (2010) 614-25. 

Friedhuber A, Wesselingh SL, Pepe S. Mitochondrial dysfunction in CD4+ lymphocytes from stavudine-treated HTV patients. Mitochondrion 2010 10(5) ... 

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