Platinum complexes spectra

Carboplatin is a platinum complex in which platinum is incorporated into a more complex molecule. Its mechanism of action and spectrum of anti-tumor activity are similar to those of cisplatin. However carboplatin is better tolerated that cisplatin. 

Reaction of the platinum complex with a molar excess of racemic acrylamide 7 leads to four distinct AB quartets in the 31P-NMR spectrum (with associated platinum satellites) due to the four possible diastereomeric species. These are formed by nonselective binding of the Re-and 57-face of both enantiomers. Such behaviour may be expected when the stereogenic center under examination is remote from the metal center. After reaction of the ethene complex with carvone 8 the metal is bound with complete stereoselectivity to the less hindered Si- 5/-face of the endocyclic, electron-poor double bond. Spectra of optically pure and racemic carvone complexes are shown in Figure 14. 

Fig. 15. The stereoisomeric thiourea-platinum complexes shown in (a) display large 4/ptjC couplings for the a-carbon atom in that branch of the X.X-dialkyl substituent which is in a favourable W configuration with respect to the metal atom (thick bonds). The assignment of the (fortuitously overlapping) H and 195Pt NMR signals of all three stereoisomers was feasible by means of indirect detection of these couplings from a XH detected H/(13C)/195Pt correlation spectrum which is shown in (b) together with the one-dimensional and 195Pt NMR projections. Reproduced from Ref. 44 by permission of John Wiley Sons.

Pinacolone, o-(diphenylphosphino)benzoyl-coordination chemistry, 401 Piperidine, IV-hydroxy-metal complexes, 797 pA a values azole ligands, 77 Plant roots amino acids, 962 carboxylic acids, 962 Plastocyanin copper binding site, 557 copper(II) complexes, 772 copper(II) site in, 770 Platinum, dichlorobis(benzonitrile)-IR spectrum, 264 Platinum, cis-dichlorodianunine-antitumor activity, 34, 979 Platinum, ethylenebis(triphenylphosphine)-reactions with 5,6-dimethyl-2,l,3-benzothiadiazole, 194 Platinum blue formation, 265 Platinum complexes acetylacetone reactions, 380 amides, 491 amidines... 

Consequently, the presence of the SnCl2 promotes the reaction between molecular hydrogen and the platinum complex. Further, with PEt3 as tertiary phosphine, we have observed the P-31 spectrum of... 

Although the visible and ultraviolet spectra of the platinum metal complexes serve as a valuable means to follow their reactions, this feature is especially disturbing to one who is trying to establish the energy states for a particular species. Some care is necessary to establish that the measured spectrum results from the particular complex species of interest, and not some of its reaction products. Water is an effective nucleophile for these complexes. To avoid solvation of some platinum complexes, Mason and Gray (21) have recently reported spectra of the tetrabutyl-... 

In the search for a more snccessful drag, numerous alternative concepts in the design of new platinum drags emerged. Requirements that have inflnenced the search for new complexes inclnde rednction in toxicity, increased spectrum of activity, circumventing resistance, and oral activity to facihtate ontpatient treatment. The remainder of this section will give an overview of the various approaches used, classical and novel. Platinum complexes with appended functionalities will be discussed in more detail. 

Consider the following H-decoupled P spectrum of the platinum complex with the structure illustrated (the resonances of the anion are omitted) ... 

Obtain one-dimensional ll spectrum and a two-dimensional COSY spectrum from 0 to 10 ppm. Assign and analyze your peaks and the shifts brought about by platinum complex binding. 

Protonation of tetrafluoroethylene platinum complexes L2Pt(C2F4) with trifluoroacetic acid gives tetrafluoroethyl complexes L2Pt-(CF2CF2H)(OCOCF3). (128) The NMR spectra showed the illustrated trans stereochemistry for complexes [233] and [234], but the H spectrum of [235] confirmed that it was the cw-isomer the main signal... 

The platinum complex formed in the reaction between C6(CF3)6 and tris(triethylphosphine)platinum shows only a single band at 30°C [5 -51-2, y(P-CFj) 3-0, /(Pt-CFj) 27-5 Hz], which must result from fluxional behaviour in solution, since X-ray crystallography shows the structure of the solid to be as in [370], with alternate long and short bonds in the non-planar C6 ring. (159, 160) At — 90°C the spectrum... 

The INS spectra of ethene complexes of rhodium and iridium and of the platinum complex, Zeise s salt, K[Pt(C2H4)Cl3], help in the assignment of the the spectrum of adsorbed ethene. 

Reactions of neutral platinum complexes with nucleic acid components in vitro. Changes in the ultraviolet absorption spectrum of salmon sperm DNA after reaction with either cis or... 

CpG and d - pCpG Platinum Complexes, In each case two isomers, ( 15%) and Z ( 85%) in the HPLC elution order, are obtained that equilibrate after separation at room temperature. The 400 MHz H NMR spectrum of their mixture is presented on Figure 1 for the CpG case. The comparative H NMR data of the oxy and deoxy isomers are collected in Table II together with those of the G-N7 monocoordina ted complex [ Pt(dien) (CpG) ] Br2, Like in the GG series, there is an overall similarity between the CpG and the d - pCpG complexes,... 

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