Appended functionality

Typical systems. A considerable number of immobilized polyether systems have been synthesized both for phase transfer catalysis as just discussed and for use in a number of analytical applications. Such immobilized systems are generally synthesized by either copolymerization of suitably functionalized macrocycles in the presence of cross-linking agents or by appending functionalized macrocycles to existing polymeric substrates. Structures (184)-(186) give examples of different... 

There has been considerable interest shown in the design and synthesis of functionalized crown ethers, and in whether the appended functional group can then further complex the cation. Examples include the so-called lariat ethers, which may be functionalized on either N or C bridgeheads in the ligand frameworks (89).427... 

In the search for a more snccessful drag, numerous alternative concepts in the design of new platinum drags emerged. Requirements that have inflnenced the search for new complexes inclnde rednction in toxicity, increased spectrum of activity, circumventing resistance, and oral activity to facihtate ontpatient treatment. The remainder of this section will give an overview of the various approaches used, classical and novel. Platinum complexes with appended functionalities will be discussed in more detail. 

Bazureau et al. reported the synthesis of novel ester and carbonyl groups appended functionalized grafted ionic liquid phases. Two synthetic strategies were developed for the preparation of the ionic liquid phases (Scheme 16) [96],... 

Scheme 16 Ester and carbonyl groups appended functionalized ionic liquid phases...

To explore structure-function relationships and optimize their activities, NeuAc-substituted acrylamide polymers were prepared with a variety of appended functional groups (Fig. 22) [99]. These studies generated polymers with very high inhibitory potencies toward HA. For example, an acrylamide copolymer substituted with 10% benzylamine and 20% NeuAc residues had a Ki of 0.6 nM [100]. Both the chelate effect and steric stabilization were mechanisms suggested to contribute to the potent activity of this and related materials (Fig. 5). The NeuAc-substituted acrylamide... 

The careful selection of the reactive building blocks ( reactophores ) is a key issue as they predetermine the core stmcture and the appended functional groups. Orthogonally protected functional groups minimise the number of chemical transformations on the solid support and thus will increase the overall yield. 

Water-soluble cydophanes are also studied as possible catalysts or artificial enzymes the hydrophobic cav-itiy serves as substrate binding site while appended functional groups act as cofactors. The pyruvate oxidase mimic 20 performed remarkably in the oxidation of aromatic aldehydes to the cossesponding esters (MeOH/ H2O), and it displayed Michaelis-Menten kinetics comparable to those of natural enzymes. The encapsulation of cydophanes in dendrimers creates binding sites within microenvironments, resembling those existing in protein superstructures. 

This relation is traditionally called append in Prolog in accordance with the append-function in LISP. Append as the relation name, however, is disadvantageous, since it stresses the procedural aspect of concatenation over the declarative one. Different from LISP, Prolog s append can be used to split a list into all possible sublists as well ... 

Appended Functionality Coplanar with the Pincer Chelate... 

Appended Functionality Copianar with the Pincer Chelate 79... 

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