Platinum complexes radiosensitization

Douple EB, Richmond RC. Platinum complexes as radiosensitizers of hypoxic mammalian cells. Br J Cancer 1978 37(Suppl III) 98—102. 

Zimbrick JD, Aruni S, Richmond RC. Studies on radiosensitization of Escherichia coli cells by cis-platinum complexes. Int J Radiat Oncol Biol Phys 1979 5 1351-1354. 

Stratford IJ, Williamson C, Adams GE. Combination studies with misonidazole and a cis-platinum complex cytotoxicity and radiosensitization in vitro. BrJ Cancer 1980 41 517-522. 

The combination of radiotherapy and chemotherapy is a promising approach because of its independent cell kill effect and the property of some cytotoxic agents to enhance the effect of radiotherapy. At the end of the 1970s, platinum complexes were described as being able to act as potent radiosensitizers of hypoxic tumor cells (Dou-PLE and Richmond 1978,1979). As an obstacle in this type of chemoradiation, Koukourakis etaL (2002) have suggested that (hypoxia-induced ) overexpression of HIF-1 a in patients with head and neck cancer may be related to substantial resistance to carboplatin chemo-radiotherapy. More in-depth research is needed to accurately characterize adverse effects of hypoxia in this type of combination therapy. 

Cooper C, Liu G-Y, Niu Y-L, Santos S, Murphy LC, Watson PH (2004) Intermittent hypoxia induces proteasome-de-pendent down-regulation of estrogen receptor a in human breast carcinoma. Clin Cancer Res 10 8720 8727 Dachs GU, Tozer GM (2000) Hypoxia modulated gene expression Angiogenesis, metastasis and therapeutic exploitation. Eur J Cancer 36 1649 1660 Di Paolo A, Bocci G (2007) Drug cUstribution in tumors mechanisms, role in drug resistance, and methods for modification. Curr Oncol Rep 9 109 114 Douple EB, Richmond RC (1978) Platinum complexes as radiosensitizers of hypoxic mammalian cells. Br J Cancer Suppl 3 98-102... 

The electron affinity of 3-(iV-methylpiperazino)-5-nitroindazole, 3,5-dinitroindazole, and molecular complex of the last with water is discussed on the basis of their half-wave potentials and in connection with their eventual radiosensitizing properties [667], The mechanism of EC behavior of 2-substituted 5(6)-nitrobenzimidazoles in acetonitrile has been investigated by classical polarography, cyclic voltammetry, and platinum rotating disk electrode with a ring (RDER) [888,991], It is shown that... 

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