Platinum chloro -, trans

Cl2N202PtC6Hi4, Platinum(ll), c -dichlorobis-(propanoneoxime)-, 34 82 Cl2N202PtC6Hi4, Platinum(ll), trans-dichlom-bis(propanoneoxime)-, 34 83 Cl2N3PtC4Hi3, Platinum(ll), chloro(diethylene-triamine)-, chloride, 34 78 Cl2N3PtC9H23, Platinum(ll),... 

ClHgNjOgPt, Platinum(II), diamineaqua-chloro-, trans-, nitrate, 22 125 CIIrOPCi7H22, Iridium(I), carbonylchlorobis-(dimethylphenylphosphine)-, trans-, 21 97... 

The trans- [chloro(isocyanide)bis(triethylphosphine)platinum(Il)] perchlorate complexes used below were prepared by the method of Church and Mays.6... 

PtClP2C24)H4, Platinum(II), chloro-(cw-l,2-diphenylethenyl)bis(triethylphosphine)-trans-, 26 140... 

A solution of 1.38 g. of irons-chloro-(p-fluorophenyldiimide)-bis(triethylphosphine)platinum(II) tetrafluoroborate in 10 ml. of methanol is stirred and cooled to 0°C. in a 50-ml. Erlenmeyer flask while a solution of 0.27 g. of sodium acetate trihydrate in 5 ml. of 50% aqueous methanol is added over a period of 1 minute. The mixture becomes red immediately, and a violet precipitate forms. The mixture is stirred for 5 minutes at 0°C. and then is filtered promptly. After drying under vacuum to remove methanol, recrystallization from hexane (about 30 ml.) gives rose-colored needles (m.p. 116-117°C.) of trans-chloro-... 

Spectroscopic and crystallographic studies of platinum-base complexes give some insight into the reactivity of the platinum compounds and their possible binding sites on DNA. The reactions of the different nucleosides or nucleotides with the chloro and aquo derivatives of O Cs- and trans-DDP have been studied by UV spectroscopy (36), raman difference spectrophotometry (37) and high pressure liquid chromatography (38). For both chloro isomers, the rates of the reactions with various nucleic acid monomers show the following trend GMP > AMP > CMP and dG > dA > dC T, The dichloro and diaquo derivatives react slowly with thymidine and UMP (37) or not at all (38, 39). 

C1PRuC3oHj4, Ruthenium(ll), chloro(Ti -hexamethylbenzene)hydrido(tri-phenylphosphine)-, 26 181 ClP2PtCgH,9, Platinum(II), chlorohydrido-bis(trimethylphosphine)-, trans-, 29 190... 

In 1936 K. A. Jensen (2, 3) measured the moments of a number of platinum (II) dihalido complexes with tertiary phosphines and other such hgands. He showed that the cis complexes had moments of up to about 11.0 Debye units (D) and that atom polarization in complex compounds is much higher than in organic compounds. He also showed that all the complexes of this type had had their cis or trans configurations incorrectly assigned on the basis of color, in analogy with the diammine di-chloro platinum (II) complexes. 

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