Platinol - Cisplatin

Platinol (Cisplatin) N/A, Paragraph HI Certification Formulation 1 Beginning 2 months prior to the last patent claiming the drug expired 30 months Between 100 and 250 million... 

Accutane - isotretinoin Gemzar- gemcitabine Platinol - cisplatin... 

The anticancer drug Platinol (Cisplatin), Pt(NH3)2Cl2, reacts with the cancer cell s DNA and interferes with its growth, (a) What is the mass % of platinum (Pt) in Platinol (b) If Pt costs 19/g, how many grams of Platinol can be made for 1.00 million (assume that the cost of Pt determines the cost of the drug) ... 

Testicular carcinoma The PVB regimen, which includes Platinol (cisplatin), vinblastine, and bleomycin, is the original treatment. A more recently introduced regimen (PEB), in which vinblastine is replaced by etoposide, is equally effective and better tolerated, so it is now considered first-line. 

Figure 3.116 Platinum compounds studied for possible anti-tumour activity. I, ris-Dichlorodi-ammineplatinum(II) cisplatin, platinol NSC 119875 neoplatin platinex. II, a.s-Diammine(l,l-cyclobutanedicarboxylato)platinum(II) JM-8 paraplatin NSC 241240. Ill, Oxiplatin. IV, Tetraplatin. V, Amminediacetatodichloro(cyclohexylamine)platinum(IV). VI, cis-Dich oro-trans-dihydroxy-cis-bis(isopropylamine)platinum(IV) iproplatin JM-19 CHIP NSC 256927.

The mechanism of action of this unrelated group of drag is not entirely clear. Examples of miscellaneous antineoplastics include cisplatin (Platinol) and hydroxyurea (Hydrea). 

A few antineoplastic drugs require treatment measures before administration. An example of preadiniiiistration treatment is hydration of the patient witii 1 to 2 liters of IV fluid infused before administration of cisplatin (Platinol) or administration of an antiemetic before the adiniiiistration of mechbretiiamine These measures are ordered by the primary health care provider and, in some instances, may vary slightly from the manufacturer s recommendations. 

Pt Cisplatin, platinol, cisDDP cis-[Pt(NH3)2Cl2] Anticancer agent... 

Bristol-Myers Squibb Co. (Bristol) distributes cisplatin (known by the brand names of Platinol and Platinol-AQ ), which is approved for treatment of testicular, ovarian and bladder cancer. Bristol s patent listings in the Orange Book and related patent infringement suits demonstrate that doublepatenting and lengthy pendency of a patent application can generate an automatic 30-month stay on FDA approval of generic products close to their otherwise expected approval date. 

Platinol is sold as a freeze-dried (lyophilized) form of cisplatin, which is dissolved in water prior to injection. Platinol AQ is a sold as a solution of cisplatin with the water already added. Bristol received approval to market Platinol in 1978 and Platinol AQ in 1988. 

In a classic case of serendipity, cisplatin (PLATINOL ), a key component of the combination therapy which revolutionised treatment of testicular cancer [ 1 ], was uncovered fortuitously in the 1960s during studies on the effect of an electric current on the growth of E. coli [ 17,18]. Cell division was inhibited not by the electric current but by production of a platinum complex from the... 

Cisplatin (Platinol, Platmol AQ) Oxaliplatin (Eloxatm) Procarbazine (Matulane)... 

Cisplatin (Platinol) is an inorganic coordination complex with a broad range of antitumor activity. It is especially useful in the treatment of testicular and ovarian cancer. It binds to DNA at nucleophilic sites, such as the N7 and 06 of guanine, producing alterations in DNA structure and inhibition of DNA synthesis. Adjacent guanine residues on the same DNA strand are preferentially cross-linked. This platinating activity is analogous... 

Cisplatin [Platinol] Carcinoma of bladder, ovaries, testicles, and other tissues Nephrotoxicity Gl distress [nausea, vomiting] neurotoxicity [cranial and peripheral nerves] hypersensitive reactions [e.g., flushing, respiratory problems, tachycardia]... 

BEP Bleomycin, etoposide, cisplatin (Platinol) Germ cell tumors... 

In summary, available reports confirm that the cisplatin is not adversely affected by normal room irradiation for 24 hours or up to 72 hours, after dilution in 0.9% sodium chloride solution (36-38). The accelerated decomposition of cisplatin by UV-VIS radiation has been demonstrated by the studies of Cubbels et al. (39). Solutions exposed to UV-VIS radiation (300-35,000 lux) for two weeks, degraded more rapidly than solutions protected from radiation. The observed degradation rate constant, obtained from log concentration-time curves of these samples, was determined to be 0.385 per day = 6.5 hours). The manufacturer states that a cisplatin solution removed from its amber vial should be protected from UV-VIS radiation if it is not used within six hours, or if it is exposed to direct sunlight (Technical Information, Platinol, Bristol-Myers Squibb). 

Cisplatin (Cis-DDP Platinol-Bristol-Myers Squibb Oncology, and others)... 

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