Inorganic coordination complexes

Cisplatin (Platinol) is an inorganic coordination complex with a broad range of antitumor activity. It is especially useful in the treatment of testicular and ovarian cancer. It binds to DNA at nucleophilic sites, such as the N7 and 06 of guanine, producing alterations in DNA structure and inhibition of DNA synthesis. Adjacent guanine residues on the same DNA strand are preferentially cross-linked. This platinating activity is analogous... 

A final example concerns the formation of heteropolynuclear hydroxide complexes.116 The complexes [(OH)Fe(OH)2Cr]3+, [(OH)Fe(OH)2Cr(OH)]2+ and [(OH)2Fe(OH)2Cr(OH)]+, or polymers such as Fe(OH)2M "+ (M = V, Cr, Mn, Co, Ni, Cu n = 2-4) have been studied with a view to an understanding of the inclusion of transition metals in iron ores as mixed oxides rather than their occurrence as discrete mineral phases. Many other examples might have been chosen in this section. Reference should be made to the general reviews given above. However it should be clear that simple inorganic coordination complexes play a major role in the chemistry of natural aqueous systems at low temperatures. 

The IR-spectra of very many — perhaps most — new inorganic coordinate complexes are yearly recorded. Most of these spectra are just fingerprinting and identification purposes or for empirical correlations and predictions. There is a definite need to put most of these empirical correlations — some of the evidence is usually very flimsy, spectroscopically speaking, and the reader is warned not to put too much faith in it - on a firmer footing through normal-coordinate analyses. Only a few solid state compounds were described by such theoretical techniques in the past few years, the most important being listed below. 

Penland, R.B., Lane, T.J. and Quaglino,J.V (1956) Infrared absorption spectra of inorganic coordination complexes. VII. Structural isomerism of nitro- and nitritopentam-minecobalt(III) chlorides./. Am. Chem. Soc., 78, 887-889. 

The boundary between organometallic and inorganic coordination complexes is not a precise one note the borderline behavior of iridium(l). 

These computational studies are comparable to those described in the section covering Type I CSPs. Experimentally the only difference between these separations and those above is that here the selectors are not stationary phases but rather are co-additives that form the diastereomeric complexes. Because no computational studies on type IV CSPs exist, molecular modeling of inorganic coordination complexes directed towards rationalizing enantioselective binding and chiral recognition presents itself as a ripe area for exploration. 

Attention will be focused on phosphates of metallic elements and other small cations (H+, NH4+), although it should be noted that a variety of phosphate salts of large organic or inorganic coordination complex cations are also known. Background information of the chemistry of phosphates and related phosphorus species can be found in the texts by Corbridge and Kanazawa (see also Phosphorus Inorganic Chemistry). 

A very important use of XRD is in the determination of the structure of single crystals, that is, identifying the exact position in 3D space of every atom (molecules, ion) in the crystal. Single crystal XRD was a major tool in elucidating the structure of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA), insulin, vitamins, and proteins. Single crystal diffractometry is used for structural determination of biomolecules, natural products, pharmaceuticals, inorganic coordination complexes, and organometallic compounds. 

For this discussion, our goal is (1) to describe the properties of typical organometallic compounds relevant to both EDA complex formation and electron transfer, (2) to discuss the electronic and structural charges attendant upon complex formation, and (3) to consider the consequences of the photoinduced electron transfer from the donor to the acceptor by irradiation of the CT band of the EDA complex according to Scheme II. Sensitized organometallic electron-transfer [25] and EDA complexation among inorganic coordination complexes [26] have been previously reviewed and will not be discussed. +... 

The Nobel prizes awarded in the field of physical chemistry, kinetics, and catalysis (Table 1.4) reflect the ongoing scientific progress in these fields. Nobel prizes for heterogeneous catalytic reactions have been awarded in the early part of this century. Many current major catalytic processes still owe their origin to that period. In the middle of this century, organometallic systems and inorganic coordination complexes formed the basis of catalytic innovations. In the last two decades, the application of zeolites has been the basis of several new processes. 

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