Platinol

Figure 3.116 Platinum compounds studied for possible anti-tumour activity. I, ris-Dichlorodi-ammineplatinum(II) cisplatin, platinol NSC 119875 neoplatin platinex. II, a.s-Diammine(l,l-cyclobutanedicarboxylato)platinum(II) JM-8 paraplatin NSC 241240. Ill, Oxiplatin. IV, Tetraplatin. V, Amminediacetatodichloro(cyclohexylamine)platinum(IV). VI, cis-Dich oro-trans-dihydroxy-cis-bis(isopropylamine)platinum(IV) iproplatin JM-19 CHIP NSC 256927.

The mechanism of action of this unrelated group of drag is not entirely clear. Examples of miscellaneous antineoplastics include cisplatin (Platinol) and hydroxyurea (Hydrea). [Pg.592]

A few antineoplastic drugs require treatment measures before administration. An example of preadiniiiistration treatment is hydration of the patient witii 1 to 2 liters of IV fluid infused before administration of cisplatin (Platinol) or administration of an antiemetic before the adiniiiistration of mechbretiiamine These measures are ordered by the primary health care provider and, in some instances, may vary slightly from the manufacturer s recommendations. [Pg.594]

Pt cw-[Pt(amine)2X2] Anticancer agents Platinol Paraplatin Eloxatine Testicular, ovarian, colon cancers... [Pg.812]

Pt Cisplatin, platinol, cisDDP cis-[Pt(NH3)2Cl2] Anticancer agent... [Pg.269]

Platinol AH, see Bis(2-ethylhexyl) phthalate Platinol DOP, see Bis(2-ethylhexyl) phthalate... [Pg.1506]

Platinol (Cisplatin) N/A, Paragraph HI Certification Formulation 1 Beginning 2 months prior to the last patent claiming the drug expired 30 months Between 100 and 250 million... [Pg.65]

For Neurontin and Platinol, the second stay was generated by a patent that had been pending for an extended period in the Patent OfiBce. In the case of Neurontin, the 482 patent had been pending for ten years. In the case of Platinol, U.S. Patent No. 5,562,925 had been pending for 26 years before it issued. [Pg.66]

Bristol-Myers Squibb Co. (Bristol) distributes cisplatin (known by the brand names of Platinol and Platinol-AQ ), which is approved for treatment of testicular, ovarian and bladder cancer. Bristol s patent listings in the Orange Book and related patent infringement suits demonstrate that doublepatenting and lengthy pendency of a patent application can generate an automatic 30-month stay on FDA approval of generic products close to their otherwise expected approval date. [Pg.118]

Platinol is sold as a freeze-dried (lyophilized) form of cisplatin, which is dissolved in water prior to injection. Platinol AQ is a sold as a solution of cisplatin with the water already added. Bristol received approval to market Platinol in 1978 and Platinol AQ in 1988. [Pg.118]

In a classic case of serendipity, cisplatin (PLATINOL ), a key component of the combination therapy which revolutionised treatment of testicular cancer [ 1 ], was uncovered fortuitously in the 1960s during studies on the effect of an electric current on the growth of E. coli [ 17,18]. Cell division was inhibited not by the electric current but by production of a platinum complex from the... [Pg.5]

Cisplatin (Platinol, Platmol AQ) Oxaliplatin (Eloxatm) Procarbazine (Matulane)... [Pg.37]

Cisplatin (Platinol) is an inorganic coordination complex with a broad range of antitumor activity. It is especially useful in the treatment of testicular and ovarian cancer. It binds to DNA at nucleophilic sites, such as the N7 and 06 of guanine, producing alterations in DNA structure and inhibition of DNA synthesis. Adjacent guanine residues on the same DNA strand are preferentially cross-linked. This platinating activity is analogous... [Pg.651]

The Federal Trade Commission sues Bristol-Myers Squibb for blocking the sale of generic drugs, particularly the cancer drugs Platinol and Taxol and the antianxiety drug BuSpar. In a settlement, the company agrees not to engage in these types of unlawful behaviors. [Pg.113]

Cisplatin [Platinol] Carcinoma of bladder, ovaries, testicles, and other tissues Nephrotoxicity Gl distress [nausea, vomiting] neurotoxicity [cranial and peripheral nerves] hypersensitive reactions [e.g., flushing, respiratory problems, tachycardia]... [Pg.578]

BEP Bleomycin, etoposide, cisplatin (Platinol) Germ cell tumors... [Pg.583]

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