Plastics drug interactions

Yahya AM, McElnay JC, D Arcy PF. 1998. Drug sorption to glass and plastics. Drug Metab. Drug Interact. 6(1) 1-45. 

D Arcy PF. 1996. Drug interactions with medicinal plastics. Adv. Drug React. Toxicol. Rev. 15(4) 207-219. 

Anonymous. Drug interactions with medical plastics. Drug Intell Clin Pharm 1983 17(10) 726-31. 

Multiple agents inducing hormetic dose response relationships display interactions that are equal to or greater than additive responses. However, a key feature of hormetic drug-drug interactions is that they would be expected to be constrained by the response ceiling effect. Thus, the resultant interactions likely would not increase the response beyond that imposed on the system by its inherent plasticity. The maximum interaction response therefore likely would be within two-fold of the control value. However, the doses of individual agents needed to achieve the effect could be profoundly lowered by the interaction. 

Centeno RF, Yu YL. The propcanolol-epineii ne interaction revisited a serious and potentially catastrophic adverse drug interaction in facial plastic suigery. Plast Reconstr Swg... 

Possible priming procedures for available plastic spacers should be studied with respect to stability, toxicity, drug interactions, and impact on patient compliance. 

Protein microarrays are small chips made of glass, plastic, or silicon that enable the study of protein-protein, protein-antibody, and protein-drug interactions in a miniaturized, automated fashion. 

The qualitative considerations of the previous section regarding the solubility of plasticizers/drug/polymer blends can be transferred into a quantitative prediction of miscibility by calculation of the Flory-Huggins interaction parameter x [48]... 

Sorption is defined as the bonding of a solute to a plastic. It is a physicochemical phenomenon related to the properties of the plastic and the chemical structure of the drug or other soluble components of the preparation. Interactions of this type can be determined by measuring the loss of the solute to the plastic at equilibrium under constant temperature conditions [11]. 

Zhao, Y., White, M.A., Muralidhara, B.K., Sun, L., Halpert, J.R. and Stout, C.D. (2006) Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole insight into P450 conformational plasticity and membrane interaction. The Journal of Biological Chemistry, 281, 5973-5981. 

Admixture incompatibility- Do not mix or dilute with other solutions or drugs in syringe or infusion flask. Diazepam interacts with plastic containers and administration sets, significantly decreasing availability of drug delivered. 

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