Plasmodium falciparum cytotoxicity against

Rhus retinorrhoea Steud. ex Olive (leaves) Biflavanone (I-25,II-25)-I-7,II-7-di-0-methyl-I-2,3,II-2,3-tetrahydroamento-flavone (56). Used in traditional medicine because of the antimicrobial and cytotoxic properties. Insecticidal activities against aphids. Moderate antimalarial activity against Plasmodium falciparum (W2 Clone) weak activity against P. falciparum (D6 Clone). Ahmed et ah, 2001[68]. 

Garcinia livingstonei T. Anderson (root bark) en/-Naringeninyl-(I-3 a,II-8)-II-4 -0-methylnaringenin (171). (+)-volkensiflavone (154) (+)-morelloflavone (159). Antiparasitic activity against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei, and T. cruzi, and cytotoxicity against MRC-5 cells. Mbwambo et al., 2006[85]. 

Six naphthoquinone derivatives, including two new compounds, 4-O-methyl erythrostominone (46) and compound (47), were isolated as antimalarial and cytotoxic constituents of Cordyceps unilateralis BCC 1869 (Kittakoop et al., 1999). Compound (46) and four known erythrostominones exhibited in-vitro antimalarial activity against Plasmodium falciparum K1 (IC50 4.0—10 p,g/mL),... 

In recent literature [101] the synthetic compound 3,15-di-O acetylbruceolide (230), a derivative from bruceoside showed a potent in vitro antimalarial activity against Plasmodium falciparum equivalent to that of chloroquine (225) [102] and also a potent in vivo activity against Plasmodium berghei in mice, with low cytotoxicity against mouse mammary tumor, representing a model in the same host. 

An aqueous ethanolic (50%) extract of fresh leaves of H. coronarium from Brazil showed hypotensive [209] and diuretic [216] activities in rat. Leaf essential oil ofH. coronarium had anti-bacterial activity [217]. Stems ofH. coronarium were reported to possess anti-cercarial activity [218]. An ethanolic extract of the stems of H, coronarium showed anti-malarial activity against Plasmodium falciparum and also possessed cytotoxic activity [211]. Petroleum ether extract of the dried entire plants of H. 

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