Plasminogen streptokinase

Fig. 4. Fibrinolytic system where SCUPA is single-chain urokinase plasminogen activator rTPA is recombinant tissue plasminogen activator APSAC is acylated plasminogen streptokinase activator complex SK is streptokinase and UK is urokinase.

APSAC = acylated plasminogen streptokinase activator complex. [Pg.180]

Acyclo-retinoic acid, 17 662 Acylaminoanthraquinone dyes, 9 333, 334 Acylated plasminogen-streptokinase activator complex, 5 175, 177-178 Acylates, titanium, 25 96 Acylating agents, 12 174 Acylation, 9 282 12 173-188... [Pg.15]

Anistreplase (anisoylated plasminogen streptokinase activator complex APSAC) consists of a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme s active site. When administered, the acyl group spontaneously hydrolyzes, freeing the activated streptokinase-proactivator complex. This product (recently discontinued in the USA) allows for rapid intravenous injection, greater clot selectivity (ie, more activity on plasminogen associated with clots than on free plasminogen in the blood), and more thrombolytic activity. [Pg.766]

Anisoylated plasminogen streptokinase complex (anistreplase) Urokinase Fibrin specific... [Pg.136]

Common Name Eminase Fibrit Iminase Multilase Anisoylated plasminogen streptokinase activator complex... [Pg.345]

J, L, Anderaon, J. B. Boissel, and D. A. Chamberlain, eds. Symposium on nnisoylnted plasminogen streptokinase activator complex (AFSAQ, Drugs3-33 (1987)-... [Pg.72]

Bernat A, Vallee E, Maffrand JP (1986) A simple experimental model of thrombolysis in the rat effect of urokinase and of the complex human plasminogen-streptokinase. Thromb Res 44 Suppl VI 112... [Pg.290]

Streptokinase is the oldest available fibrinolytic. By itself it lacks enzymatic activity only after binding to a plasminogen molecule is a complex formed that activates plasminogen. Streptokinase is produced by streptococcal bacteria. Streptokinase antibodies may be present as a result of previous streptococcal infections and may lead to incompatibility reactions. [Pg.150]

Anistreplase (anisoylated plasminogen streptokinase activator complex, APSAC), is the plasminogen-streptokinase complex (above) in which the enzyme centre that converts plasminogen to plasmin is protected from deactivation, so prolonging its action. [Pg.578]

Been M, de Bono DP, Muir AL, Boulton FE, Fears R, Standring R, Ferres H. Clinical effects and kinetic properties of intravenous APSAC—anisoylated plasminogen-streptokinase activator complex (BRL 26921) in acute myocardial infarction. Int J Cardiol 1986 11(1) 53-61. [Pg.3406]

Bucknall C, Darley C, Flax J, Vincent R, Chamberlain D. Vasculitis complicating treatment with intravenous anisoy-lated plasminogen streptokinase activator complex in acute myocardial infarction. Br Heart J 1988 59(1) 9-11. [Pg.3408]

Anisoylated Plasminogen-Streptokinase Activator Compiex APSAC) (Eminase)... [Pg.73]

Anistreplase This anisoylated plasminogen-streptokinase activator complex (APSAC) is a prodrug. As the anisoyl group is hydrolyzed in vivo (a slow, spontaneous process), the... [Pg.308]

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human plasma-derived Lys-plasminogen proteins. [Pg.725]

Commonly used thrombolytics are streptokinase, urokinase, tissue plasminogen activator (t-PA, Alteplase), anisoylated plasminogen streptokinase activator complex (APSAC, Anistreplase), and reteplase (Retavase). [Pg.390]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...