Anisoylated plasminogen streptokinase activator

Anistreplase (anisoylated plasminogen streptokinase activator complex APSAC) consists of a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme s active site. When administered, the acyl group spontaneously hydrolyzes, freeing the activated streptokinase-proactivator complex. This product (recently discontinued in the USA) allows for rapid intravenous injection, greater clot selectivity (ie, more activity on plasminogen associated with clots than on free plasminogen in the blood), and more thrombolytic activity. 

Chemical Name Anisoylated plasminogen streptokinase activator complex... 

Anistreplase (anisoylated plasminogen streptokinase activator complex, APSAC), is the plasminogen-streptokinase complex (above) in which the enzyme centre that converts plasminogen to plasmin is protected from deactivation, so prolonging its action. 

Been M, de Bono DP, Muir AL, Boulton FE, Fears R, Standring R, Ferres H. Clinical effects and kinetic properties of intravenous APSAC—anisoylated plasminogen-streptokinase activator complex (BRL 26921) in acute myocardial infarction. Int J Cardiol 1986 11(1) 53-61. 

J. L. Anderson, J. B. Boissel, and D. A. Chamberlain, eds. Symposium on anisoylated plasminogen streptokinase activator complex (APSAC). Drugs 3 33 (1987). 

Anisoylated Plasminogen-Streptokinase Activator Compiex APSAC) (Eminase)... 

Anistreplase This anisoylated plasminogen-streptokinase activator complex (APSAC) is a prodrug. As the anisoyl group is hydrolyzed in vivo (a slow, spontaneous process), the... 

Commonly used thrombolytics are streptokinase, urokinase, tissue plasminogen activator (t-PA, Alteplase), anisoylated plasminogen streptokinase activator complex (APSAC, Anistreplase), and reteplase (Retavase). 

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