Plasma protein childhood levels

In the former study, we determined the CML content of infant formulas, and CML levels in plasma and urine of breast- and formula-fed babies. CML has no intrinsic fluorescence, thus its contribution to protein glycation is not directly assessed by measuring skin autofluorescence. In the present study, a fluorimetric technique was used to determine the MRPs content of infant formulas and human milk. AGEs/MRPs-related fluorescence was also measured in plasma and urine in a large cohort of healthy 3-12 month-old infants, either breast- or infant formula-fed at the time of investigation, or formerly. To reveal whether the intake of a MRPs-rich diet in early childhood affects the glycation of long-lived proteins, skin auto fluorescence was assessed in a different cohort of healthy 1-29 month-old infants. 

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