Piscidins

Piscidins are 22-amino acid long peptides with conserved N-termini, which represent a new family of antimicrobial peptides isolated from the mast cells of fish. Piscidin 1, derived from hybrid-striped bass, displays good inhibitory properties and has the amino acid sequence... 

Piscidin 1 and its analogues Piscidin 1 and its analogues PIIIA toxin Tetrodotoxin-resistant Na+ channel binding by p-conotoxin smlllA C. purpurascens Conus stercusmuscarum... 

Piscidin 1 and its analogues AMP distinctin in water MII-7, cyclic conotoxin Morone Phyllomedusa distincta... 

Gotten and coworkers have studied two antimicrobial peptides, piscidin 1 3 in two different bilayers (3 1 PC/PG and 1 1 PE/PG) to investigate their structure and dynamics as well as their role in membrane destabilization in bacterial cell membrane mimics and their antimicrobial capacity. They combine oriented sample solid-state NMR by measuring the dipolar couplings and N chemical shifts and MD... 

From Osteichthyes, piscidins are a new family of AMPs isolated from a hybrid striped bass Morone saxatilis (male) X Morone chrysops (female). Some AMPs from fish are displayed in Figure 29.7. 

Noga, E.J. and Silphaduang, U. (2003) Piscidins A novel family of peptide antibiotics from frsh. Drug Nem Perspect., 16,87-92. 

Piscidins are a family of AMPs found in a fish species and show broad-spectrum activity against bacteria, fungi and viruses (Cole et al, 1997 Yin et /., 2006 Fernandes et al, 2010). These molecules have a marked amphipa-thic character, due to well-defined hydrophobic and hydrophilic regions, and most are linear peptides with less than 26 residues and a high proportion of basic amino acids (phenylalanine and isoleucine). They are unstructured in water but have a high a-helix content in dodecylphosphocholine (DPC) micelles, a structure similar to those determined for other cationic peptides involved in permeabilization of bacterial membranes (Campagna et al., 2007). 

The piscidins of the hybrid striped bass (Morone chrysops female x Morone saxatilis male) were the first to be shown to reside within mast cells (Silphaduang and Noga, 2001). This phenomenon is now known to be widespread in a number of fish species (Fernandes et al., 2010). Four piscidins (1 ) have been isolated from hybrid striped to date, with piscidin-4 being unusual in being twice as long (44 amino acids) as typical members of the piscidin family (Park et al., 2011). 

CAMPAGNA s, SAINT N, MOLLE G, AUMELAS A (2007), Structure and mechanism of action of the antimicrobial peptide piscidin . Biochemistry, 46,1771-8. 

DEZFULI BS, PIRONI F, GIARI L, NOGA EJ (2010), Immunocytochemical localization of piscidin in mast cells of infected seabass gill . Fish Shellfish Immunol, 28,476-82. 

FERNANDES JMO, RUANGSRi J, KutoN V (2010), Atlantic cod piscidin and its diversification through positive selection PLoS One, 5, e9501. 

PARK NG, SILPHADUANG U, MOON HS, SEO JK, CORRALES J, NOGA EJ (2011), StrUCtUre-activity relationships of piscidin 4, a piscine antimicrobial peptide . Biochemistry, 50,3288-99. 

The main linear fish AMPs are piscidins, pleurocidins, cathelicidins and pardaxins (Table 17.1) and their classification in the above mentioned groups is based on sequence homology. 

Piscidins 18 4 4 exons 3 introns Acanthopterygii and Paracanthopterygii superorder [70, 75-77,79]... 

NOGA EJ, siLPHADUANG u. Piscidins a novel family of peptide antibiotics from fish. Drug News Perspect 2003 Mar 16(2) 87-92. 

SILPHADUANG u, coLORNi A, NOGA EJ. Evidence for widespread distribution of piscidin antimicrobial peptides in teleost fish. Dis Aquat Organ 2006 Oct 27 72(3) 241-52. 

NOGA EJ, SIUHADUANG U, PARK NG, SEO JK, STEPHENSON J, KOZLOWICZ S. Piscidin... 

SUN BJ, XIE Hx, SONG Y, NiE p. Gene strnctnre of an antimicrobial peptide from mandarin fish, Siniperca chuatsi (BasUewsky), snggests that moronecidins and pleurocidins belong in one family the piscidins. J Fish Dis 2007 Jnn 30(6) 335-43. 

CORRALES J, MULERO I, MULERO V, NOGA EJ. Detection of antimicrobial peptides related to piscidin 4 in important aqnacnltnred fish. Dev Comp Immunol 2010 Mar 34(3) 331-43. 

CHEKMENEV EY, VOLLMAR BS, FORSETH KT, MANION MN, JONES SM, WAGNER TJ, et al. Investigating molecular recognition and biological function at interfaces using piscidins, antimicrobial peptides from fish. Biochim Biophys Acta 2006 Sep 1758(9) 1359-72. 

SUNG ws, LEE I, LEE DG. Fungicidal effect and the mode of action of piscidin 2 derived from hybrid striped bass. Biochem Biophys Res Common 2008 Jul 4 371(3) 551-5. 

COLORNI A, ULLAL A, HEiNiscH G, NOGA EJ. Activity of the antimicrobial polypeptide piscidin 2 against fish ectoparasites. J Fish Dis 2008 Jun 31(6) ... 

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