Piperonyl chloride

In a flask with stirring is added 158g piperonyl chloride or 126g... 

Benzhydrylamine Derivatives Attachment of piperazine nitrogen directly to a benzhydryl carbon leads to a pair of compounds which show vasodilator activity, and which should be useful in disease states marked by impaired blood circulation. Reaction of piperonyl chloride (18) with a mixture of piperazine and piperazine dihydrochloride leads to the monoalkylation product (19). (It may be supposed that the mixture of free base and salt equilibrates to the monobasic salt, thus making the second amine less nucleophilic.) Alkylation of 19 by means of benzhydryl chloride then... 

The piperonyl ester can be prepared from an amino acid ester and the benzyl alcohol (imidazole/dioxane, 25°, 12 h, 85% yield) or from an amino acid and the benzyl chloride (Et3N, DMF, 25°, 57-95% yield). It is cleaved, more readily than a p-methoxybenzyl ester, by acidic hydrolysis (CF3COOH, 25°, 5 min, 91% yield). ... 

For tissue analysis, the sample is extracted with ethyl acetate in the presence of sodium chloride and piperonyl butoxide. After centrifugation, the supernatant is evaporated to dryness, and the residue is dissolved with dichloromethane/ hexane (1 1) to be applied onto a Bond-Elut silica cartridge. Following successive cartridge washing with petroleum ether and ethyl acetate/hexane (4 6), chloramphenicol is eluted with ethyl acetate/hexane (7 3) and the eluate is evaporated to dryness. The residue is dissolved in 0.05 M Tris/hydrochloric acid buffer pH 10.4, extracted with diethyl ether, and the extract is evaporated to dryness. Tlie... 

To a solution of 32 g piperonyl piperazine in 100 ml anhydrous toluene, 10 g sodium carbonate are added and 35.2 g benzhydryl chloride are added dropwise. The mixture is then heated to reflux for 7 hours with vigorous agitation. Then the mixture is cooled, the salt that has formed is filtered out and 100 ml water is added. The organic layer is extracted with several batches of 10% methane sulfonic acid. The acid extracts are combined and... 

Methylenedioxy)benzyl esters (piperonyl esters) are cleaved more readily than the 4-methoxybenzyl ester by acid hydrolysis with 2 M HBr/AcOH or TFA at room temperature within 5 minutes.3,4-(Methylenedioxy)benzyl esters are readily prepared either by transesterification of anoino acid 4-nitrophenyl esters with 3,4-(methylenedioxy)benzyl alcohol in imidazole/dioxane (rt, 12 h) or from Nps-protected amino acids with 3,4-(methyl-enedioxy)benzyl chloride/TEA in DMF at room temperature. 

UNSYMMETRICAL, 11, 88 Picryl chloride, 13, 37 Pimelic acid, 11, 43 Pinacol hydrate, 13, 111 Pinacolone, 14, 88 Piperonal, 10, 82 Piperonylic ACID, 10, 82 Pivaloin, 13, 26... 

Costa et al. developed an efficient pathway utilizing a chiral auxiliary to enter the monobutyrolactone skeleton, Scheme (9) [56]. The carboxylic acid 48 was transformed into the corresponding acyl chloride and then esterified using a homochiral enantiomeric alcohol 49. The resulting ester 50 was deprotonated with LDA and alkylated with piperonyl iodide providing the alkylated ester 51 in 62% yield and high diastereomeric excess (94% de). Ester 51 was reduced to the homoallylic alcohol 52 and finally transformed into the desired lactone 29 either by ozonolysis of the... 

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