Piperonyl

Supplement 1952 2666-3031 Carbonyl compounds Ethylene carbonate, 100. Piperonal, 116. Thioindigo, 177. Fluorescein, 222. Carboxylic acids Piperonylic acid, 269. Amines, 328. Three Cyclic Oxygens, 381. Four Cyclic Oxygens, 433. Fiite Cyclic Oxygens, 459.. . . ... 

I ve found that unfortunately, there is a hyper oxydation of oleofin as side reaction, and gives organic acids, probably MDPhenylace-tic acid and may be a bit of piperonylic acid. It s easy to realise it. 

METHOD 6 This one is for meth cooks only as it is only practical for making P2P, not MD-P2P because Strike don t know where one can get piperonylic acid . It has been around awhile and works really well [20]. Therefore the chemicals needed have been restricted for quite some time. But if one can get them then what the hell. 

This is a way to do this procedure without having to use one of those crazy tube furnaces stuffed with thorium oxide or manganous oxide catalyst [21]. The key here is to use an excess of acetic anhydride. Using even more than the amount specified will insure that the reaction proceeds in the right direction and the bad side reaction formation of dibenzylketone will be minimalized (don t ask). 18g piperonylic acid or 13.6g phenylacetic acid, 50mL acetic anhydride and 50mU pyridine are refluxed for 6 hours and the solvent removed by vacuum distillation. The remaining residue is taken up in benzene or ether, washed with 10% NaOH solution (discard the water layer), and vacuum distilled to get 8g P2P (56%). 

METHOD 7 Another piperonylic acid method for your perusal [22, 23]. 70g piperonylic acid or 65g phenylacetic acid in 250mL DCM is stirred in a flask and 64g SOCb is added dropwise. The solution is heated to reflux until no more HCI gas is released from the solution. The chemist should have a tube leading from the top of the reflux condenser to a glass of water to catch all that HCI... 

In a flask with stirring is added 158g piperonyl chloride or 126g... 

Piperonyl butoxide [51-03-6] is 5-[2-(2-butoxyethoxy)ethoxy]methyl-6-propyl-l,3-benzodioxole (11) d 1.04—1.07, vp 0.13 kPa at 25°C). The rat oral LD qS are 7500, 6150 mg/kg. Piperonyl butoxide is the synergist commonly used with natural pyrethrins in aerosol sprays. 

Gas ehromatography mass-mass aequisition was used for the pyrethroid determination. Pyrethroids investigated were Allethrin, Prallethrin, Tetramethrin, Bifenthrin, Phenothrin, X-Cyhalothrin, Permethrin, Cyfluthrin, Cypermethrin, Flueythrinate, Fsfenvalerate, Fluvalinate and Deltamethrin. Piperonyl butoxide, main synergist eompound for pyrethroid eompounds, was also studied. 

The piperonyl ester can be prepared from an amino acid ester and the benzyl alcohol (imidazole/dioxane, 25°, 12 h, 85% yield) or from an amino acid and the benzyl chloride (Et3N, DMF, 25°, 57-95% yield). It is cleaved, more readily than a p-methoxybenzyl ester, by acidic hydrolysis (CF3COOH, 25°, 5 min, 91% yield). ... 

The formation of (A) and (C) indicates that cryptopine must have in its structure the grouping I, whilst the production of (B) and (D) shows that the alkaloid must also contain the piperonyl ring in the form of grouping II, and from these the structme of anhydrotetrahydromethyl-cryptopine is represented by formula III ... 

The piperonyl ester can be prepared from an amino acid ester and the benzyl alcohol (imidazole/dioxane, 25°, 12 h, 85% yield) or from an amino acid and the... 

Isosafrol yields piperonal (heliotropine) melting at 37° as the principal product of oxidation when potassium permanganate is used as the oxidising agent. If the oxidation be very energetic piperonylic acid, melting at 228°, is the principal reaction product. 

Insecticide Fliesa None Myristicin Piperonyl butoxide ... 

A number of synergists are used with pyrethrum to increase its toxicity. Most of the better ones, as far as flying insects are concerned, are of the methylene dioxyphenyl type. The best known of this type is piperonyl butoxide. 

Piperonyl butoxide increases the absolute toxicity of the four constituents of pyrethrum. 

Bates, Hewlett, and Lloyd (I) found that both piperonyl butoxide and SKF 525A, the ester of 2-diethylaminoethyl 2,2-diphenyl-w-pentanoate, synergized the action of pyrethrins on insects of species of the lesser mealworm beetles and houseflies but both antagonized the action of malathion. SKF 525A is known to increase the effects on mammals of drugs of various types and has been shown to synergize pyrethrins. 

Bates, Hewlett, and Lloyd (2) therefore studied the synergistic effects of some compounds related to 2-diethylaminoethyl 2,2-diphenyl-w-pentanoate on the insecticidal activity of pyrethrins. They found active compounds when a 2-diethylamino moiety was joined to the diphenylmethyl moiety through an ester, ketone, or ether linkage. However, none of the compounds investigated approached piperonyl butoxide in synergistic activity with pyrethrins. 

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