Piperis

Monochloroacetamides are cleaved (by assisted removal ) by reagents that contain two nucleophilic groups (e.g., o-phenylenediamine, thiourea, 1-piperi-dinethiocarboxamide, 3-nitropyridine-2-thione, 2-aminothiophenol ) ... 

Quinicines (inactive) (Q = 0 -methoxy-quinolyl). Dihydroquini-cinols (inactive) (Q = 6-metho-xy-quinolyl. 4-(6-Methoxy-quinolyl)-a-piperi dylcarbinol (Ainley and King), (0-5). 

An explanation of the exclusive N methylation of 1,2-dimethyl-J -piperi-deine by means of methyliodide is more difficult. Pyrrolines and piperideines which are not alkylated on the nitrogen atom afford only quaternary ammonium salts on alkylation (203-205), for example 119. 

Kinetic studies have been carried out on the displacement reactions of various chloroazanaphthalenes with ethoxide ions and piperi-dine. - 2-Chloroquinoxaline is even more reactive than 2-chloro-quinazoline, thus demonstrating the powerfully electrophilic nature of the -carbon atoms in the quinoxaline nucleus. The ease of displacement of a-chlorine in the quinoxaline series is of preparative value thus, 2-alkoxy-, 2-amino-, - 2-raethylamino-, 2-dimethyl-amino-,2-benzylamino-, 2-mercapto-quinoxalines are all readily prepared from 2-chloroquinoxaline. The anions derived from substituted acetonitriles have also been used to displace chloride ion from 2-chloroquinoxaline, ... 

The chief constitneots oI the nil arc phellandtene, encalyptol, piperi-tone, and a sesquiterpene. 

Chemical Name 1-[(4-Fluorophenyl)methyl] -N-[1 -[2-(4-methoxyphenyl)ethyl] -4-piperi-dinyl] -1 H-benzimidazol-2-amine... 

Chemical Name 10H-Pyrido[3,2-b] [1,4] benzothiadiazine-10-carboxylic acid 2-(2-piperi-dinoethoxy )ethyl ester... 

Die Spaltung von Tetrahydro-l,3-oxazinen zu 3-Amino-alkoholen kann mit Li-thiumalanat durchgefiihrt werden2,3 z.B. 5-Oxa-l-aza-bicyclo[4.4.0]decan zu 3-Piperi-dino-propanol (77% d.Th.)4 ... 

C21H2SNO2 3567-/2-2) see Pipenzolate bromide 3emfo-a-hydroxy-a-phenylbenzeneacetic acid 6-methoxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester (C23H27NO4) see Tropenziline bromide a-hydroxy-a-phenylbenzeneacetic acid l-methyl>4-piperi-dinyl ester... 

C20H22N2O2S 83863-65-4) see Levocabastine 3-methyl-l-[(4-methylphenyl)sulfonyl]-4-phenyl-4-piperi-dinecarboxylic acid... 

The Heck-Cassar-Sonogashira-Hagihara system, which couples terminal alkynes and vinylic or aromatic halides in an amine solvent, typically piperi-... 

A PCP antigen was produced by coupling the hapten 4-[(l-piperi-dinyl )cyclohexyl]benzoic acid sulfate 1/4 M hydrate (figure 2) to bovine serum albumin using 1-ethyl-3-(3-dimethylaminopropyl)carbo-diimide HC1 in aqueous dimethylsulfoxide at pH 4.0 to 4.5. The antibodies produced against this antigen have been shown to be fairly specific for PCP versus PCP metabolites (Owens et al. 

MPBT) [100], benzenesulfinyl morpholine (BSM) [101] or 1-benzenesulfinyl piperi-dine/2,4,6-tri-tert-butylpyrimidine (BSP/TTBP) [85], in combination with triflic anhydride (Tf20) provide high yields of products for difficult glycosylations. 

In this way piperidine is converted into the hydrocarbon pipery-lene , a-methylbutadiene. The cause of the shift in the double bond is the same as in the rearrangement of eugenol to isoeugenol and of /S- to a-dihydromuconic acid. Formulate this degradation reaction with f -methylpyrrolidine. 

The malonic acid derivative (1573) was prepared from diethyl 1-piperi-dinylmethylenemalonate with propen-1-yl magnesium bromide at 0°C (61BSF2423). 

However, when 6-bromo-4-phenylpyrimidine reacts with lithium piperi-dide/piperidine instead of potassium amide/liquid ammonia, it was surprisingly found that the corresponding 4-phenyl-6-piperidinopyrimidine was not obtained. Rather, the product was a compound whose structure was established to be a Z/E mixture of 2-aza-4-cyano-3-phenyl-l-piperidino-1,3-butadiene (2) (70RTC129). The presence of a cyano group in structure... 

The sensitivity of position 2 in 4-chloroquinazoline for nucleophilic addition was also demonstrated in the reaction with lithium piperidide (73RTC460). Whereas in the amination with potassium amide/liquid ammonia no open-chain intermediate could be isolated, with lithium piperi-dide/piperidine the open-chain compound ort/z6>-(piperidinomethy-leneamino)benzonitrile (78,60%) was obtained, in addition to 4-piperidino-quinazoline (80,19%) (Scheme 11.35). The formation of 80 from 78 involves... 

Piperitone, with its fresh minty camphor4ike odor, is present in various leaf essential oils. Among Mentha and Eucalyptus genera, there are piperi tone-rich species which are considered common sources of this natural monoterpene ketone. The (45) (-f)- enantiomer was reported to be... 

The amine is then used to introduce a nitrile by diazotization followed by treatment of the diazonium salt with cuprous cyanide (180) the methyl ether is then cleaved by means of aluminum chloride. Treatment of the phenolic ketone 181 with benzoyl chloride and sodium benzoate serves to build up the chromone ring (182). The nitrile is next hydrolyzed to the acid with sulfuric acid. Esterification of the carboxyl as—its acid chloride—with N-(2-hydroxyethyl)piperi-... 

Piperi, A. Stavridou, M. C. Psalli-dopoulos, and J. C. Stavrides. The cytotoxic effect of volatile organic compounds of the gas phase of cigarette smoke on lung epithelial cells. Free Radic Biol Med 2003 34(3) 345-355. 

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