Piperazine adipate

Javed, I., Akhtar, M. S., Rahman, Z. U., Khaliq, T. and Ahmad, M. (1994). Comparative anthelmintic efficacy and safety of Caesalpinia crista seed and piperazine adipate in chickens with artificially induced Ascaridiagalli infection . Acta Veterinaria Hungarica, 42(1), 103-109. 

Soluble in water and ethanol practically insoluble in ether. Piperazine Adipate... 

Guanethidine Monosulphate Mepacrine Hydrochloride Methaqualone Hydrochloride Morphine Sulphate Piperazine Adipate Sulfaquinoxaline Indoramin Hydrochloride Dexamethasone Triclocarban Racemorphan T ryptamine Hydrochloride Nefopam Hydrochloride Pentazocine Hydrochloride Protoveratrine B Morphine Bufylline... 

ADIPIC ACID, COMPOUND with PIPERAZINE (1 1) (142-88-1) see piperazine adipate. 

Piperazine Adipate. Hexanedioic acid compd with... 

The melting transition in polymers is conveniently observed by dilatometric measurements of the volume as a function of the temperature. Results thus obtained for poly-(N,N -sebacoyl piperazine) are shown in Fig. 129, and for poly-(decamethylene adipate) by the lowest curve in Fig. 130. Most of the melting, as evidenced by the abnormal increase in volume, occurs within a range of 10°, and it terminates abruptly at a temperature which may be defined within 0.5°. The data shown were obtained by raising the temperature... 

In horses, piperazine eliminates adult worms of small strongyles and P. equorutnin in more than 90% of the animals, but is less effective against S. vulgaris, S. edentatus and O.equi. The recommended dose of the drug is 90 mg (base)/kg administered orally as citrate, phosphate or adipate salts. 

Piperazine is usually given as hexahydrate or citrate, phosphate, adipate or tartrate salts as tablets or syrup. The recommended adult dose of piperazine is 50-75 mg/kg with a maximum of 3.5-4.5 g daily given for 1-2 days when almost 100% elimination of A.lumbricoides is obtained. Children under 20 kg receive a maximum of 3 g in single dose [52-56]. 

Further variations can be made by using mixtures of diesters (e.g., adipate/malonate or malonate/oxalate), or mixtures of diamines (e.g., ethylene diamine/DETA, DETA/TETA, or DETA/piperazine). These combinations (with various stoichiometric ratios) permit different polymer structures (and properties) to be obtained, particularly after the derivatization reaction (below). 

Salts of piperazine (citrate, phosphate, adipate) or its hexahydrate are used as anthelminitics. The piperazine ring is frequently used as a building block for pharmaceuticals. Benzhydrylpiperazines, such as cinnarizine 8 and its difluoro analogue flunarizine 9, possess considerable activity as peripheral and cerebral vasodilators. Hydroxyzine 10 is used as a tranquilizer ... 

In general, piperazine and a good munber of its salts e.g., adipate, calcium edetate, citrate, phosphate and tartrate— have been employed profusely in therapeutic treatment of roundworm and pinworm infections. Piperazine itself is a representative example of this class of compoimds ... 

Acrylates/VA copolymer Adipic acid Albumen Alkyl phenol disulfide Ami noethyl piperazine Ammonium lignosulfonate Ammonium perchlorate Ammonium polyacrylate Ammonium thiocyanate Ammonium zirconium carbonate Beeswax Benzidine dihydrochloride N-Benzyldimethylamine Boron trifluoride 1,3-Butanediol dimethacrylate Butyl acetoxystearate Butyl lactate t-Butyl methacrylate Calcium naphthenate p-Carboxyethyi acryiate... 

When, for example, piperazine, ethylene glycol, phosgene, and adipyl dichloride are simultaneously polycondensed, a copolymer with a more or less random distribution of monomeric units is produced. In this case, however, the sequence of monomeric units is still regulated by the fact that a B monomeric unit (carbonic acid or adipic acid) can only be followed by an A monomeric unit (piperazine or ethylene glycol). 

Fig. 5.9 Plot of l/Tm against -IhXa for copolyamides and copolyesters. A, NJ J -sebacoyl piperazine/isophttialoyl piperazine copolymer(67) B, decamethylene adipate/ decamethylene isophthalate copolymer (from Evans, Mighton, and Flory (58)) C, caproamide-hexamethylene adipamide copolymer (from Sonnerskog (60)), D, ethylene terephthalate-ethylene adipate copolymers (from Edgar and Ellery (59)X...

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