Thalictrum dasycarpum

The first occurrence of an isopavine alkaloid outside the Papaveraceae was demonstrated when (—)-thalisopavine (30) was found in Thalictrum dasycarpum (53). The proposed structure was verified through spectral analyses and total synthesis (53). Methylation yielded (—)-0-methylthalisopavine (26), which was later synthesized as a racemate (77). (—)-0-Methylthalisopavine was discovered in Papaver radicatum some years later (78), so this represents another case of synthesis preceding natural occurrence. 

N.A. Thalictrum dasycarpum Fisch. Ave-Lall. T. occidental A. Gray Thalidasine, thalicarpine, thalisopavine, corypalline, norargemonine, trans-5, cw-9-octadecadienoic acid, dasycarponin, bis-norargemonine, L-laudanidine, tram -5 -hexadecenoic acid.302-333 A tumour inhibitor, relieve dizziness and ear problems. 

Perdue, R. E., Jr. 1977. Thalictrum dasycarpum source of the antitumor agent thali-carpine. Lloydia 40 607. 

Daphne genkwa, D. mezereum Thalictrum dasycarpum, T. occidentale... 

Thalictrum dasycarpum, T occidentale Perilla frutescens Piper longum, P. nigrum Zingiber officinale Caulophyllum thalietroides Pulsatilla vulgaris... 

Fumaria bastardii (Papaveraceae) nps 4,257 98 Thalictrum dasycarpum (Ranunculaceae) jnp 46,293 83... 

Berberis nummularia (Berberidaceae) cnc 33,70 97 Berberis turcomannica (Berberidaceae) cnc 29,63 93 Berberis valdiviana (Berberidaceae) fit 64,378 93 Corydalis ophiocarpa (Papaveraceae) yz 98,1658 78 Corydalis speciosa (Papaveraceae) yz 95,838 75 Corydalis stricta (Papaveraceae) kps 19,461 83 Doryphora sassafras (Monimiaceae) 11yd 37,493 74 Islaya minor (Cactaceae) jc 189,79 80 Menispermum dauricum (Menispermaceae) tcyyk 5, 30 93 Papaver bracteatum (Papaveraceae) phy 22,247 83 Stephania cepharantha (Menispermaceae) nm 52,541 98 Thalictrum dasycarpum (Ranunculaceae) joc 34,1062 69 Thalictrum rugosum (Ranunculaceae) jnp 43,143 80 Thalictrum uchiyamai (Ranunculaceae) kjp 13,132 82 Xylopia vieillardii (Annonaceae) jnp 54,466 91... 

Biogenetic significance is attached to the fact that benzylisoquinoline alkaloids occur in the plant with bisbenzylisoquinoline alkaloids. Examples of such occurrence are thalifendlerine with hernandezine in Thalictrum fendleri (Auth. ) and magnoflorine with thalicarpine in Thalictrum dasycarpum Fisch. and Ball. In each case the simpler alkaloid may well be the precursor of the bisbenzylisoquinoline alkaloid. 

Thalicarpine (LX), C41H48O8N2 (mp 160°-161°) was first isolated from Thalictrum dasycarpum Fisch. and Lall. (30). Later it was obtained from Thalictrum minus L. var. datum Jacq. (31) and from Hernandia ovigera (Auth. ) (32). 

Thalisidine (58) from Thalictrum dasycarpum (Ranunc.) showed significant activity against the Walker carcinosarcoma in rats solapalmitine (59) and sola-... 

In fact only two alkaloids have been isolated from the roots of Thalictrum dasycarpum (Family Ranunculaceae) by systematie fraetionation namely thalicarpine and thalidasine. 

Taxus yunnanensis 409-410,413 Tetrapanax papyriferum 66 Thalictrum dasycarpum 336,341... 

Systematic fractionation of extracts of Thalictrum dasycarpum root resulted in the isolation of thalicarpine (VII), one of a new group of dimeric isoquinoline alkaloids which have antitumour activity [46], The alkaloid has subsequently been isolated from Thalictrum minus spp. datum (47], T. 

A new bisbenzylisoquinoline alkaloid, thalidasine (Xa) has been isolated from Thalictrum dasycarpum [56] and T. rugosum [57] and shown to be active against W 256. The therapieutic index of thalidasine is greater than 1-5... 

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