Drug Design, physicochemical parameters

Behind the relatively straightforward compositional nature of ophthalmic solutions, suspensions, and ointments, however, lie many of the same physicochemical parameters that affect drug stability, safety, and efficacy, as they do for most other drug products. But additionally, specialized dosage forms present the ophthalmic product designer with some extraordinary compositional and manufacturing challenges. These... 

Physiologically based pharmacokinetic models provide a format to analyze relationships between model parameters and physicochemical properties for a series of drug analogues. Quantitative structure-pharmacokinetic relationships based on PB-PK model parameters have been pursued [12,13] and may ultimately prove useful in the drug development process. In this venue, such relationships, through predictions of tissue distribution, could expedite drug design and discovery. 

Physicochemical Parameters in Drug Design Corwin Hansch 3, 348 ... 

An excellent, recently published monograph which covers the whole field of QSAR, is the book Quantitative Drug Design, volume IV of the six-volume set Comprehensive Medicinal Chemistry [39]. In addition, numerous other monographs, either directly related to QSAR methodology and applications [40—47], on physicochemical parameters [48 — 56], or on related topics [57 — 64], have been published. 

Hansch, C. (1968a) Physicochemical parameters in drug design. Ann. Rep. Med. Chem., 248-357. 

Lipophilicity is undoubtedly the most important physicochemical property used in drug design and QSAR studies. > Besides numerous experimental parameters, calculated lipophilicity properties play an important role in QSAR and drug design, as illustrated by the large number of publications devoted to such applications. Because it is impossible here to provide an exhaustive overview of these applications, we focus our attention on a few examples, giving a flavor of what can be performed with computed lipophilicity properties. 

Chapter 33. Physicochemical Parameters In Drug Design Corwin Hansch, Pomona College, Claremont, California... 

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