Photodynamic cancer

Naphthalocyanins, phthalocyanins, and porphyrins as sensitizers in photodynamic cancer therapy 98IZV836. 

Water-soluble ruthenium phthalocyanines show promise as photodynamic cancer therapy agents [129b],... 

Sortino, S., Mazzagha, A., Scolaro, L. M., Merlo, F. M., Volveri, V., and Sciortino, M. T. (2006), Nanoparticles of cationic amphiphilic cyclodextrins entangling anionic porphyrins as carrier-sensitizer system in photodynamic cancer therapy, Biomaterials, 27, 4256-4265. 

Pharmacyclics, Inc. Press Release January 7, 1997 Pharmacyclics Completes Phase I Lu-Tex Trials in Photodynamic Cancer Treatment. 

TaiUefer J, Brasseur N, van Lier JE, Ixnaerts V, Le Garrec D, Leroux JC (2001) In-vitro and in-vivo evaluation of pH-responsive polymeric miceUes in a photodynamic cancer therapy model. J Pharm Pharmacol 53 155-166... 

Lu Z-R, Shiah JG, Kopeckova P, Kopecek J. Pol3unerizable Fab antibody fragment targeted photodynamic cancer therapy in nude mice. STP Pharma Sci 2003 13 69-75. 

In 2002, Cavaleiro et al. [38] developed the stereoselective synthesis of glycoconjugated isoxazoUdine-fused chlorines (potential photosensitizers in photodynamic cancer therapy) by 1,3-dipolar cycloadditions of meso-tetrakis(pentafluorophenyl)porphyrin (83) with glycosyl nitrones 41-43 and 84. In all cases of sugar moieties, the configuration of the major products 85 indicated an endo addition, as shown in Fig. 18. 

Vaidya A, Sun Y, Feng Y, Emerson L, Jeong EK, Lu ZR. Contrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer conjugate. Pharm Res 2008 25 2002-2011. 

Figure 10.8 Photosensitizer (Ce6)-loaded plasmonic gold vesicles (GVs) for trimodality fluorescence/thermal/photoacoustic imaging guided synergistic photothermal/photodynamic cancer therapy. (Reproduced with permission from S. Wang, P. Huang, L. Nie, R. Xing, D. Liu, Z. Wang, J. Lin, S. Chen, G. Niu, G. Lu and X. Chen, Adv. Mater., 2013,25,3055. Copyright (2013) American Chemical Society. )...

Progress in this area has been considerable in recent years and hopefully some non precious metal catalyst will be used in fuel cells in the near future. On the other hand, the stability of metallophthalocyanines makes them appropriate for applications in various fields such as chemical catalysis (such as the MEROX process for the sweetening of oils), dye stuffs, coloring for plastics and metal surfaces, sensors, chromatographic detectors, photoconducting agents, and so on. These complexes are also used for photobiology and photodynamic cancer therapy, electrochemical... 

Two modified porphyrins, (59) and (60), were made as diastereomeric mixtures for use in photodynamic cancer therapy, and the antitumour etoposide VP16 (61) was made using 2,3-di(chloroacetyl)-4,6-0-ethylidene-D-glucose as glycosylating agent with BF3... 

This catalytic system operating on less electron-rich 2-naphthols complements well more traditional systems working on highly electron-rich naphthols, which have been employed in the synthesis of chiral perylenequinones-based derivatives that are potent protein kinase C inhibitors and are promising agents for photodynamic cancer therapy. ... 

Unsymmetrically substituted water-soluble phthalocyanines and naphthalocyanines as well as water-soluble tetrasubstituted phthalocyanines [R4PCM, R = COOH, SO3H M = Zn, A1(0] have been applied in photodynamic cancer therapy [109]. 

D-aminolevulinic acid Herbicide, active component in photodynamic cancer treatment... 

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